Resveratrol and Ophthalmic Diseases.
Resveratrol and Ophthalmic Diseases.
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DOI：
10.3390/nu8040200
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发表时间：
2016-04-05
期刊：
影响因子：
5.9
通讯作者：
Chalam KV
中科院分区：
文献类型：
--
作者：
Abu-Amero KK;Kondkar AA;Chalam KV
白藜芦醇是一种天然存在于葡萄中的植物多酚，是红葡萄酒中的主要生物活性成分。临床研究表明，白藜芦醇由于其有效的抗氧化和抗炎特性，具有心脏保护，化疗，神经保护和抗衰老作用。氧化应激和炎症在年龄相关性眼部疾病（青光眼、白内障、糖尿病性视网膜病变和黄斑变性）的发生和发展中起关键作用，这些疾病导致视力逐渐丧失和失明。迄今为止进行的体外和体内（动物模型）实验研究已经提供了白藜芦醇对许多途径的生物学效应的证据，这些途径包括氧化应激、炎症、线粒体功能障碍、细胞凋亡、促存活或血管生成，这些途径与这些年龄相关的眼部疾病的发病机制有关。在这篇综述中，我们提供了一个简短的概述，目前的科学文献白藜芦醇，其合理的作用机制，其潜在的用途和目前的局限性，作为一种营养治疗干预眼睛及其相关疾病。
Resveratrol, a naturally occurring plant polyphenol found in grapes, is the principal biologically active component in red wine. Clinical studies have shown that resveratrol due to its potent anti-oxidant and anti-inflammatory properties are cardio-protective, chemotherapeutic, neuroprotective, and display anti-aging effects. Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular diseases (glaucoma, cataract, diabetic retinopathy and macular degeneration) that lead to progressive loss of vision and blindness. In vitro and in vivo (animal model) experimental studies performed so far have provided evidence for the biological effects of resveratrol on numerous pathways including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, pro-survival or angiogenesis that are implicated in the pathogenesis of these age-related ocular disorders. In this review, we provide a brief overview of current scientific literature on resveratrol, its plausible mechanism(s) of action, its potential use and current limitations as a nutritional therapeutic intervention in the eye and its related disorders.