2-EVENT MODEL FOR CARCINOGENESIS - BIOLOGICAL, MATHEMATICAL, AND STATISTICAL CONSIDERATIONS
2-EVENT MODEL FOR CARCINOGENESIS - BIOLOGICAL, MATHEMATICAL, AND STATISTICAL CONSIDERATIONS
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DOI：
10.1111/j.1539-6924.1990.tb01053.x
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发表时间：
1990-06-01
期刊：
影响因子：
3.8
通讯作者：
LUEBECK, G
中科院分区：
文献类型：
--
作者：
MOOLGAVKAR, SH;LUEBECK, G
本文综述了肿瘤发生的双突变模型。讨论了模型与流行病学和实验数据拟合的一般原则，并给出了一些实例。建立了具有时间依赖参数的模型的一般解，并通过对暴露于氡的大鼠发生肺癌的实验数据的应用说明了该模型的应用。
A two‐mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time‐dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.