Intracranial haemorrhage in idiopathic thrombocytopenic purpura. Paediatric Haematology Forum of the British Society for Haematology.
Intracranial haemorrhage in idiopathic thrombocytopenic purpura. Paediatric Haematology Forum of the British Society for Haematology.
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特发性血小板减少性紫癜的颅内出血。
DOI：
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发表时间：
1994
影响因子：
5.2
通讯作者：
J. Lilleyman
中科院分区：
文献类型：
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作者：
J. Lilleyman
英国进行了一项调查，以发现儿童特发性血小板减少性紫癜（ITP）并发颅内出血（ICH）的频率、情况和结局。通过英国儿科血液学论坛的成员分发了一份调查问卷，并分发给当地的儿科医生和血液学家。它寻求关于在截至1994年1月的20年期间患有ICH的任何ITP儿童的信息。发现了14起案件，1984年之前7起，1984年之后7起。6名儿童在事件中幸存，后遗症很小或没有后遗症，4名没有开颅手术。在4例患者中发现了直接诱因; 2例有动静脉畸形，2例头部受伤。7例病例的事件发生在诊断后两周内，5例病例发生在两个月内。所有儿童在颅内出血时均为重度脑出血。通过计算，这14名儿童约占审查期间ITP患者总数的0.1%。儿童ITP中的ICH可能有诱因，但不一定致命。没有最大风险期，它可以发生在疾病过程中的任何时候，当血小板计数低于10-15 × 10（9）/l。这是一种极其罕见的事件，以前对其发病率的估计可能过高。
A UK survey was carried out to discover the frequency, circumstances, and outcome of intracranial haemorrhage (ICH) complicating idiopathic thrombocytopenic purpura (ITP) of childhood. A questionnaire was circulated through the membership of the UK Paediatric Haematology Forum, and thence to local paediatricians and haematologists. It sought information on any child with ITP who had had an ICH during the 20 year period to January 1994. Fourteen instances were discovered, seven before 1984 and seven after. Six children survived the event with minimal or no sequelae, four without craniotomy. An immediately precipitating cause was noted in four; two had arteriovenous malformations and two suffered head injuries. The event occurred over two weeks from diagnosis in seven cases and over two months in five. All children were profoundly thrombocytopenic at the time of their intracranial bleed. By calculation the 14 children would have represented some 0.1% of the total with ITP during the period under review. ICH in childhood ITP may have a precipitating cause and is not necessarily fatal. There is no period of maximum risk, and it can occur at any time during the course of the illness when the platelet count is less than 10-15 x 10(9)/l. It is an extremely rare event and previous estimates of its incidence may have been too high.