Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases.
Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases.
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DOI：
10.3390/ijms19102917
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发表时间：
2018-09-25
影响因子：
5.6
通讯作者：
Gaudio E
中科院分区：
文献类型：
--
作者：
Overi D;Carpino G;Cardinale V;Franchitto A;Safarikia S;Onori P;Alvaro D;Gaudio E
两种不同的胆道起源的干细胞/祖细胞群已经确定在成人肝脏和胆道树。肝干/祖细胞（hpsc）是位于肝管内的双能祖细胞，可分化为成熟肝细胞和胆管细胞；胆道树干细胞/祖细胞（BTSCs）是一种多能干细胞，位于肝内和肝外胆管的胆道周围腺内，能够分化为肝脏和胰腺谱系。HpSCs和BTSCs被赋予由支持细胞和细胞外基质化合物组成的特殊生态位。这些干细胞龛对肝脏和胆道稳态再生的实际贡献是微不足道的；这是由于成熟的实质细胞（即肝细胞和胆管细胞）具有高度的复制能力和可塑性。然而，对人类肝脏和胆道疾病的研究揭示了这些干细胞龛如何参与广泛和/或慢性损伤后的再生反应，并激活特定的信号通路。本文综述了干细胞/祖细胞龛在人类肝脏疾病中的作用，重点介绍了其激活机制和临床意义，包括纤维化和疾病进展。
Two distinct stem/progenitor cell populations of biliary origin have been identified in the adult liver and biliary tree. Hepatic Stem/progenitor Cells (HpSCs) are bipotent progenitor cells located within the canals of Hering and can be differentiated into mature hepatocytes and cholangiocytes; Biliary Tree Stem/progenitor Cells (BTSCs) are multipotent stem cells located within the peribiliary glands of large intrahepatic and extrahepatic bile ducts and able to differentiate into hepatic and pancreatic lineages. HpSCs and BTSCs are endowed in a specialized niche constituted by supporting cells and extracellular matrix compounds. The actual contribution of these stem cell niches to liver and biliary tree homeostatic regeneration is marginal; this is due to the high replicative capabilities and plasticity of mature parenchymal cells (i.e., hepatocytes and cholangiocytes). However, the study of human liver and biliary diseases disclosed how these stem cell niches are involved in the regenerative response after extensive and/or chronic injuries, with the activation of specific signaling pathways. The present review summarizes the contribution of stem/progenitor cell niches in human liver diseases, underlining mechanisms of activation and clinical implications, including fibrogenesis and disease progression.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
13.5
作者：
Gadd, Victoria L.;Skoien, Richard;Clouston, Andrew D.
通讯作者：
Clouston, Andrew D.
影响因子：
3.7
作者：
Della Corte C;Carpino G;De Vito R;De Stefanis C;Alisi A;Cianfarani S;Overi D;Mosca A;Stronati L;Cucchiara S;Raponi M;Gaudio E;Byrne CD;Nobili V
通讯作者：
Nobili V
DOI：
10.1016/s2468-1253(18)30163-8
发表时间：
2018-09
期刊：
The lancet. Gastroenterology & hepatology
影响因子：
--
作者：
Carbone M;Nardi A;Flack S;Carpino G;Varvaropoulou N;Gavrila C;Spicer A;Badrock J;Bernuzzi F;Cardinale V;Ainsworth HF;Heneghan MA;Thorburn D;Bathgate A;Jones R;Neuberger JM;Battezzati PM;Zuin M;Taylor-Robinson S;Donato MF;Kirby J;Mitchell-Thain R;Floreani A;Sampaziotis F;Muratori L;Alvaro D;Marzioni M;Miele L;Marra F;Giannini E;Gaudio E;Ronca V;Bonato G;Cristoferi L;Malinverno F;Gerussi A;Stocken DD;Cordell HJ;Hirschfield GM;Alexander GJ;Sandford RN;Jones DE;Invernizzi P;Mells GF;Italian PBC Study Group and the UK–PBC Consortium
通讯作者：
Italian PBC Study Group and the UK–PBC Consortium
DOI：
10.1073/pnas.1302168110
发表时间：
2013-04-16
影响因子：
11.1
作者：
Bird, Thomas G.;Lu, Wei-Yu;Forbes, Stuart J.
通讯作者：
Forbes, Stuart J.