Reduced hepatic functional reserve in cirrhosis and obstructive jaundice with special reference to histological morphometric analysis and galactose elimination capacity
Reduced hepatic functional reserve in cirrhosis and obstructive jaundice with special reference to histological morphometric analysis and galactose elimination capacity
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DOI：
10.1159/000129474
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发表时间：
1996-09-01
影响因子：
1.6
通讯作者：
Nakajima, N
中科院分区：
文献类型：
--
作者：
Kaiho, T;Miyazaki, M;Nakajima, N
为了评价梗阻性黄疸（OJ）患者的肝功能障碍，对肝组织的形态学和功能进行了分析，并与肝硬化（LC）进行了比较。对30例肝切除术后的患者，采用形态计量学方法测定肝实质总比值（THPR），半乳糖耐量试验（GaTT）测定肝功能质量。肝硬化患者的GaTT值明显低于肝功能正常者（P < 0.001）。在OJ中也被抑制（与正常肝脏相比p < 0.05），但低于LC（p < 0.05）。然而，THPR仅在LC中降低（与正常肝脏或OJ相比p < 0.05）。在LC患者中，GaTT和THPR值之间存在显著相关性，但在OJ患者中不存在相关性。这些结果表明，肝功能障碍在OJ是独立的肝细胞数量减少，不同于LC。
To evaluate liver dysfunction in patients with obstructive jaundice (OJ), morphological and functional hepatic mass was analyzed in comparison with cirrhosis (LC). Total hepatic parenchymal ratio (THPR) was estimated by morphometric analysis and hepatic functional mass by galactose tolerance test (GaTT) in 30 patients who underwent hepatectomy. The value of GaTT in patients with LC was remarkably depressed compared to those with normal liver function (p < 0.001). It was also depressed in OJ (p < 0.05 vs. normal liver), but less than in LC (p < 0.05). However, THPR decreased only in LC (p < 0.05 vs. either normal liver or OJ). A significant correlation between the value of GaTT and THPR was revealed in patients with LC, but not in OJ. These results suggested that liver dysfunction in OJ was independent of the decreased number of hepatocytes, differing from LC.