Retinal Microvasculature Alteration in High Myopia
Retinal Microvasculature Alteration in High Myopia
复制标题
高度近视的视网膜微血管改变
DOI：
10.1167/iovs.16-19542
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发表时间：
2016-11-01
影响因子：
4.4
通讯作者：
Shen, Meixiao
中科院分区：
文献类型：
--
作者：
Yang, Ye;Wang, Jianhua;Shen, Meixiao
目的.探讨高度近视眼视网膜血管网的改变。21名受试者的33只高度近视眼和24名健康对照受试者的47只轻度近视或正视眼入组。光学相干断层扫描血管造影术（OCTA）被用来成像的表面，深，整个视网膜血管丛在黄斑区。高度近视的眼睛图像进行分析后，调整眼睛放大率使用班尼特的公式。在大血管和微血管的不同环形和象限区中进行代表血管密度的分形分析（盒计数法，D-盒）。分析了血管密度、眼轴长度和等效球镜屈光不正之间的相关性。高度近视眼视网膜浅环形区（0.6-2.5 mm）微血管的平均密度（Dbox）为1.741 ± 0.018，显著低于对照组（1.773 ± 0.010，P < 0.001）。高度近视眼的单个环形区（带宽为0.16 mm）分析显示，与对照眼的相同区域相比，所有区域的微血管改变均具有显著性水平（P < 0.001）。高度近视组眼轴各层微血管密度与眼轴长度均呈显著正相关（r = -0.38 ~-0.48; P < 0.05）。本研究揭示了高度近视眼视网膜微血管网络的改变，这与眼轴长度延长相关。通过OCTA图像对微血管进行分形分析，可能有助于描述高度近视的病理生理机制。
PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes.METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett's formula. Fractal analysis (box counting method, D-box) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed.RESULTS. The average density (Dbox) of the superficial retinal annular zone (0.6-2.5 mm) microvessels was 1.741 +/- 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 +/- 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r = -0.38 to -0.48; P < 0.05).CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.