DEVELOPMENT OF AUDITORY BRAIN-STEM RESPONSE TO TONE PIP STIMULI IN THE RAT
DEVELOPMENT OF AUDITORY BRAIN-STEM RESPONSE TO TONE PIP STIMULI IN THE RAT
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DOI：
10.1016/0165-3806(87)90140-4
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发表时间：
1987-03-01
期刊：
影响因子：
--
通讯作者：
COLEMAN, JR
中科院分区：
文献类型：
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作者：
BLATCHLEY, BJ;COOPER, WA;COLEMAN, JR
本文观察了大鼠听性脑干反应（ABR）的发育过程。在出生后第9、10、12、14、16、20、24、36、70和96天对麻醉大鼠进行3、8和40 kHz的纯音PIP刺激，强度高达106 dB声压级峰值当量。在每个刺激参数下检查每个波的峰-峰振幅和出现顺序。在PND 12观察到对听觉刺激呈现的第一反应。这种反应被证明是非神经源性的，并推测是代表耳蜗毛细胞功能的总和电位。第一个神经反应，观察PND 14，13和8 kHz的音调，出现两个或多个波。高频（40 kHz）音调没有引起任何实质性的神经反应PND 14，但神经活动，这种刺激观察到一致的PND 16。到PND 20时，在所有测试频率下一致地存在4个波，到PND 36时，记录到5个顶点阳性波的完整成人补体。在发展过程中的波的频率依赖性的顺序出现的支持数据图表的发展频率映射在耳蜗。波I和II的振幅在8 kHz下降，随着动物的成熟，而波III-V一般表现出在所有测试频率的振幅通过PND 24的初始增加，随后逐渐降低到成人水平的振幅。振幅的发展变化的可能来源进行了讨论。
The course of development of the auditory brainstem response (ABR) in rat was examined. Pure tone pip stimuli of 3, 8 and 40 kHz at intensities up to 106 dB sound pressure level peak equivalent were presented to anesthetized rats on postnatal days (PND) 9, 10, 12, 14, 16, 20, 24, 36, 70 and 96. The peak-to-peak amplitude and the order of appearance of each wave was examined at each stimulus parameter. The first response to presentation of an auditory stimulus was observed on PND 12. This response was demonstrated to be of non-neural origin and presumed to be a summating potential representing hair cell function in the cochlea. The first neural responses, observed on PND 14, to 13- and 8-kHz tones only, appeared as two or more waves. High-frequency (40 kHz) tones did not elicit any substantive neural response on PND 14, but neural activity to this stimulus was observed consistently by PND 16. By PND 20, 4 waves were present consistently at all test frequencies, and by PND 36 the full adult complement of 5 vertex positive waves was recorded. The frequency-dependent sequential appearance of waves during development lends support to data charting the development of frequency mapping in the cochlea. The amplitude of waves I and II at 8 kHz decreased, as the animal matured, while waves III-V generally showed an initial increase in amplitude at all test frequencies through PND 24 followed by a gradual amplitude decrease to adult levels. Possible sources for developmental changes in amplitude are discussed.