Suppression of vagal cardiac modulation by blue light in healthy subjects.
Suppression of vagal cardiac modulation by blue light in healthy subjects.
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DOI：
10.1186/s40101-016-0110-x
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发表时间：
2016-10-05
影响因子：
3.1
通讯作者：
Hayano J
中科院分区：
文献类型：
--
作者：
Yuda E;Ogasawara H;Yoshida Y;Hayano J
在当代生活环境中，我们的身体越来越多地暴露在各种彩色光源下，这可能会以非成像效应的形式影响我们的生理功能。我们通过分析心率变异性 (HRV) 来研究彩色光对自主神经功能的影响。在遮光实验室中，将一个由四个有机发光二极管 (OLED) 模块 (55 × 55 mm2) 组成的可调节红绿蓝颜色的照明装置固定在距仰卧受试者眼睛上方 24 厘米处。仰卧休息 15 分钟后，在 3 分钟黑暗、6 分钟彩色 OLED 照明和 3 分钟黑暗定速呼吸（15 次呼吸/分钟）期间连续测量心电图和呼吸。在 12 名健康受试者（23±2 岁，两名女性）中，以 45 分钟间隔重复测量红光、绿光和蓝光，黑视素刺激光子通量密度 (MSPFD) 分别为 0.00、0.10 和 0.20 μmol/m2/s。此外，在四名健康受试者（25-39 岁，两名女性）中检查了蓝光与 0.20、0.10 和 0.04 μmol/m2/s MSPFD 的影响。分析 HRV 的低频（LF，0.04–0.15 Hz）和高频（HF，0.20–0.30 Hz）功率以及低频与高频比率（LF/HF）。与照明前的黑暗相比，所有颜色光的平均值在照明期间高频功率下降（P < 0.001）并且LF/HF增加（P = 0.024），而蓝光下的高频功率比红光和绿光显示出更大的下降（两者均P < 0.05）。即使在照明后的黑暗中，高频功率的下降也持续存在（P < 0.001）。当 MSPFD 为 0.20 μmol/m2/s 时，高频功率随蓝光降低（P < 0.001），但与 0.10 或 0.04 μmol/m2/s 时的高频功率无关（分别为 P = 0.1 和 0.9）。在健康受试者中，迷走神经心脏调节被 OLED 蓝光抑制，很可能是通过黑视蛋白依赖性非成像效应。
In the contemporary life environments, our body is increasingly exposed to various sources of colored light, which may affect our physiological functions as non-image-forming effects. We examined the impacts of colored lights on the autonomic functions by the analysis of heart rate variability (HRV). A lighting device consisting of four organic light-emitting diode (OLED) modules (55 × 55 mm2) with adjustable red-green-blue color was secured 24 cm above the eyes of subject lying supine in a light-shielded laboratory. Following a 15-min supine rest, electrocardiogram and respiration were measured continuously during 3-min darkness, 6-min colored OLED illumination, and 3-min darkness under paced breathing (15 breath/min). The measurements were repeated at a 45-min interval for red, green, and blue lights with melanopsin-stimulating photon flux density (MSPFD) of 0.00, 0.10, and 0.20 μmol/m2/s, respectively, in 12 healthy subjects (23 ± 2 years, two females). Additionally, the effects of blue lights with 0.20, 0.10, and 0.04 μmol/m2/s MSPFD were examined in four healthy subjects (25–39 years, two females). HRV was analyzed for low-frequency (LF, 0.04–0.15 Hz) and high-frequency (HF, 0.20–0.30 Hz) power and LF-to-HF ratio (LF/HF). Compared to darkness before lighting, HF power decreased (P < 0.001) and LF/HF increased (P = 0.024) during lighting on average of all color lights, whereas HF power showed a greater decrease with blue light than with red and green lights (P < 0.05 for both). The decrease in HF power lasted even during darkness after lighting (P < 0.001). HF power decreased with blue light with 0.20 μmol/m2/s MSPFD (P < 0.001) but not with that with 0.10 or 0.04 μmol/m2/s (P = 0.1 and 0.9, respectively). Vagal cardiac modulation is suppressed by OLED blue light in healthy subjects most likely through melanopsin-dependent non-image-forming effect.
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影响因子：
--
作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
影响因子：
3.5
作者：
al Enezi, Jazi;Revell, Victoria;Lucas, Robert
通讯作者：
Lucas, Robert
影响因子：
--
作者：
HIRSCH, JA;BISHOP, B
通讯作者：
BISHOP, B
影响因子：
--
作者：
Litscher, Daniela;Wang, Lu;Litscher, Gerhard
通讯作者：
Litscher, Gerhard
影响因子：
3.3
作者：
MUKAI, S;HAYANO, J
通讯作者：
HAYANO, J