Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.
Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example.
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以治疗相关的转移性乳腺癌进展为例对研究的解释和临床护理转化的视角。
DOI：
10.1007/s10585-017-9872-8
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发表时间：
2017
影响因子：
4
通讯作者：
BoardoftheMetastasisResearchSociety
中科院分区：
文献类型：
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作者：
Fingleton,Barbara;Lange,Kelly;Caldwell,Beth;Bankaitis,KatherineV;BoardoftheMetastasisResearchSociety
这篇评论是转移研究协会董事会和两名转移性乳腺癌患者合作撰写的。它的构思是为了回应临床前科学研究有时以一种可能导致压力和困惑的方式呈现给非科学家。将临床前研究结果转化为临床需要克服多重障碍。这与研究结果是否与新疗法的令人兴奋的反应有关或当前使用的疗法的问题效果有关。在总结研究结果以供主流报告时，理解和承认这些障碍非常重要。为了最大程度地减少混乱，患者应继续依靠肿瘤护理团队来帮助他们解释主流媒体中提出的研究结果是否与其个人护理相关。实验室和临床研究人员应尽可能共同努力，为转移性疾病患者提供更多选择，这些患者仍然迫切需要有效的治疗方法。
This commentary was written as a collaboration between the Board of the Metastasis Research Society and two patients with metastatic breast cancer. It was conceived in response to how preclinical scientific research is sometimes presented to non-scientists in a way that can cause stress and confusion. Translation of preclinical findings to the clinic requires overcoming multiple barriers. This is irrespective of whether the findings relate to exciting responses to new therapies or problematic effects of currently used therapies. It is important that these barriers are understood and acknowledged when research findings are summarized for mainstream reporting. To minimize confusion, patients should continue to rely on their oncology care team to help them interpret whether research findings presented in mainstream media have relevance for their individual care. Researchers, both bench and clinical, should work together where possible to increase options for patients with metastatic disease, which is still in desperate need of effective therapeutic approaches.