Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia
Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia
复制标题
DOI：
10.1046/j.1365-2990.2000.00255.x
复制
发表时间：
2000-08-01
影响因子：
5
通讯作者：
Nottet, HSLM
中科院分区：
文献类型：
--
作者：
Boven, LA;Middel, J;Nottet, HSLM
在人类免疫缺陷病毒（HIV）-1相关性痴呆（HAD）中，浸润单核细胞和脑内皮细胞之间相互作用的后果尚未完全了解。这项研究调查了HAD患者脑组织中的血脑屏障是否受到影响，以及是否有可能发现与单核细胞存在或不存在的相关性，这些单核细胞被认为在HAD中起主要作用。紧密连接蛋白1和巨噬细胞标记物CD 68的免疫组织化学分析显示，紧密连接免疫反应性的丧失与单核细胞浸润和HAD高度相关。这表明血管周围巨噬细胞的存在与血脑屏障的破坏相关，从而促进更多单核细胞的浸润，从而促进疾病进展。
In human immunodeficiency virus (HIV)-1-associated dementia (HAD), consequences of interactions between infiltrating monocytes and brain endothelial cells are not yet fully understood. This study investigated whether the blood-brain barrier is affected in brain tissue of patients suffering from HAD and whether it was possible to find a correlation with the presence or absence of monocytic cells, which have been suggested to play a major role in HAD. Immunohistochemical analysis for zonula occludens 1, a tight junction protein, and CD68, a macrophage marker, revealed that loss of tight junction immunoreactivity was highly correlated with monocyte infiltration and with HAD. This suggests that the presence of perivascular macrophages cells is associated with breakdown of the blood-brain barrier thereby facilitating infiltration of more monocytic cells hence enhancing disease progression.