IMMUNOLOGICAL PARAMETERS OF PERIPARTURIENT HOLSTEIN CATTLE - GENETIC-VARIATION
IMMUNOLOGICAL PARAMETERS OF PERIPARTURIENT HOLSTEIN CATTLE - GENETIC-VARIATION
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DOI：
10.3168/jds.s0022-0302(94)77205-2
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发表时间：
1994-09-01
影响因子：
3.5
通讯作者：
KELLEY, DH
中科院分区：
文献类型：
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作者：
DETILLEUX, JC;KOEHLER, KJ;KELLEY, DH
对137头荷斯坦奶牛产前35d至产后35d血液中性粒细胞功能、淋巴细胞对有丝分裂原刺激反应、血清Ig浓度、血清补体和凝集素活性的遗传变异进行了研究。围产期奶牛在产犊时会经历各种免疫参数的免疫抑制。遗传力估计是在免疫抑制事件发生之前、期间和之后获得的。中性粒细胞总数、中性粒细胞趋化作用、与吞噬相关的中性粒细胞呼吸爆发的测定(细胞色素C减少、化学发光和碘化)、血清免疫球蛋白G(1)、免疫球蛋白G(2)和免疫球蛋白M的浓度以及血清溶血补体活性在围产期发生了显著的遗传变异。这种变异性表明，免疫图谱可用于选择先天免疫反应增强的牛，而不会对产奶量产生不利影响。然而，这些结果应该被认为是试探性的，因为数据中包含的观察数据的数量有限。
The genetic variability of blood neutrophil functions, lymphocyte blastogenic responses to mitogens, serum Ig concentrations, and serum complement and conglutinin activities was investigated from 35 d prepartum to 35 d postpartum for 137 Holstein cows. Periparturient cows experience an immunosuppression of various immunologic parameters at calving. Heritability estimates were obtained before, during, and after the episodes of immunosuppression. Significant genetic variability occurred in the periparturient changes for total number of neutrophils, neutrophil chemokinesis, assays of the neutrophil respiratory burst associated with phagocytosis (cytochrome c reduction, chemiluminescence, and iodination), serum concentrations of IgG(1), IgG(2), and IgM, and serum hemolytic complement activity. This variability implies that immune profiles could be used for the selection of cattle with improved innate immune response without adverse effects on milk productivity. These results should be considered tentative, however, because the number of observations included in the data were limited.