Low expression of nucleus accumbens-associated protein 1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma
Low expression of nucleus accumbens-associated protein 1 predicts poor prognosis for patients with pancreatic ductal adenocarcinoma
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DOI：
10.1111/pin.12020
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发表时间：
2012-12-01
影响因子：
2.2
通讯作者：
Tajima, Yoshitsugu
中科院分区：
文献类型：
--
作者：
Nishi, Takeshi;Maruyama, Riruke;Tajima, Yoshitsugu
伏隔核相关蛋白1 （NAC1）在多种癌中过表达，包括卵巢癌、宫颈癌、乳腺癌和胰腺癌。高表达NAC1被认为通过负调控生长停滞和dna损伤诱导的45-？相互作用蛋白1 （GADD45GIP1）在卵巢癌和宫颈癌中的作用。本研究采用免疫组织化学和计算机辅助图像分析方法检测NAC1在胰腺导管腺癌（pancreatic ductal adenocarcinoma， PDA）中的表达，探讨其与各种临床病理参数及预后的相关性。与高nac1 PDA患者相比，低nac1 PDA患者总生存期较差（P = 0.0010），无病生存期较短（P = 0.0036）。这与卵巢癌和宫颈癌的临床效果相反。此外，在胰腺癌细胞系中，敲低NAC1并不会增加GADD45GIP1蛋白的表达。这些结果表明，NAC1调控的基因因癌类型或起源组织的不同而不同，NAC1的低表达预示着PDA患者的预后不良。
Nucleus accumbens-associated protein 1 (NAC1) is overexpressed in various carcinomas including ovarian, cervical, breast, and pancreatic carcinomas. High expression of NAC1 is considered to have adverse effects on prognosis through negative regulation of growth arrest and DNA-damageinducible 45-? interacting protein 1 (GADD45GIP1) in ovarian and cervical carcinomas. In the present study, the expression of NAC1 in pancreatic ductal adenocarcinoma (PDA) was measured using immunohistochemistry and computer-assisted image analysis in order to investigate its correlation with various clinicopathological parameters and prognosis. Patients with low-NAC1 PDA had worse overall survival (P = 0.0010) and a shorter disease-free survival (P = 0.0036) than patients with high-NAC1 PDA. This was a clinical effect opposite to that reported in ovarian and cervical carcinomas. Furthermore, knockdown of NAC1 in pancreatic carcinoma cell lines did not increase expression of the GADD45GIP1 protein. These results indicate that the gene(s) regulated by NAC1 vary depending on the types of carcinoma or originating tissue, and that low expression of NAC1 predicts poor prognosis for patients with PDA.