Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments
Transient 23-30 Hz oscillations in mouse hippocampus during exploration of novel environments
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DOI：
10.1002/hipo.20435
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发表时间：
2008-01-01
期刊：
影响因子：
3.5
通讯作者：
Greene, Robert W.
中科院分区：
文献类型：
--
作者：
Berke, Joshua D.;Hetrick, Vaughn;Greene, Robert W.
海马体是对新经历和新环境进行编码的关键大脑结构。海马体活动表现出明显的振荡模式，但振荡与记忆之间的关系尚不清楚。在这里，我们描述了在探索新的但不熟悉的环境时，类似于23-30赫兹（β 2）振荡的小鼠海马爆发。与相对稳定的类似于8赫兹的θ节奏形成鲜明对比的是，β 2的能量在新环境的第一圈很弱，当老鼠重新到达起点时急剧增加，然后只持续几分钟。新奇诱发的振荡反映了单个神经元的精确同步，参与的锥体细胞表现出选择性的空间特异性增强。通过局灶病毒操作，我们发现新奇诱发的振荡需要CA3中的功能性NMDA受体，CA3是体外快速振荡的关键亚区。这些发现表明，β 2振荡表明海马体的动态状态促进了独特情境表征的形成。(c) 2008 Wiley-Liss, Inc。
The hippocampus is a key brain structure for the encoding of new experiences and environments. Hippocampal activity shows distinct oscillatory patterns, but the relationships between oscillations and memory are not well understood. Here we describe bursts of hippocampal similar to 23-30 Hz (beta2) oscillations in mice exploring novel, but not familiar, environments. In marked contrast to the relatively invariant similar to 8 Hz theta rhythm, beta2 power was weak during the very first lap of the novel environment, increased sharply as the mice reencountered their start point, then persisted for only a few minutes. Novelty-evoked oscillations reflected precise synchronization of individual neurons, and participating pyramidal cells showed a selective enhancement of spatial specificity. Through focal viral manipulations, we found that novelty-evoked oscillations required functional NMDA receptors in CA3, a subregion critical for fast oscillations in vitro. These findings suggest that beta2 oscillations indicate a hippocampal dynamic state that facilitates the formation of unique contextual representations. (c) 2008 Wiley-Liss, Inc.