A Comparison of Human Pulmonary Arterial and Venous Prostacyclin and Thromboxane Synthesis- Effect of a Thromboxane Synthase Inhibitor
A Comparison of Human Pulmonary Arterial and Venous Prostacyclin and Thromboxane Synthesis- Effect of a Thromboxane Synthase Inhibitor
复制标题
人肺动脉和静脉前列环素和血栓素合成的比较 - 血栓素合酶抑制剂的效果
作者：
A. Carter;J. Bevan;S. Hanley;W. Morgan;D. Turner
总结测量了从接受胸外科手术的患者中获得的成对人肺动脉和静脉样本的内皮表面产生的6-酮-前列腺素F1α（6-酮-PGF 1 α）和血栓素B2（TxB 2）的量。动脉和静脉产生6-keto-PGF_（1 α）和TxB_2的量无明显差异。然而，动脉和静脉产生的6-keto-PGF 1 α均多于TxB 2，两者的比例约为7.5：1。动脉和静脉合成6-keto-PGF_（1 α）呈显著正相关，而TxB_2的相对含量无相关性。静脉6-keto-PGF 1 α合成与TxB 2合成相关，但动脉无相关性。12份动脉样本中有8份显示出一定程度的内膜纤维化。与血栓素合酶抑制剂达唑昔本孵育，导致血管TxB 2合成的显著抑制和6-酮-PGF 1 α合成的显著增加。在5例病例中，3例6-keto-PGF 1 α升高幅度过大，无法用TxB 2下降解释。
Summary The amounts of 6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B2 (TxB2) produced by the endothelial surfaces of paired samples of human pulmonary arteries and veins, obtained from patients undergoing thoracic surgery, were measured. The amounts of 6-keto-PGF1α and TxB2 produced by arteries compared with veins were not different. However, both arteries and veins produced more 6-keto-PGFlα than TxB2, the ratio being approximately 7.5:1 for both. 6-keto-PGFlα synthesis by arteries was significantly correlated with that produced by veins but the relative amounts of TxB2 were not correlated. 6-keto-PGFlα synthesis was correlated with TxB2 synthesis for veins but not for arteries. 8 of the 12 arterial samples exhibited some degree of intimal fibrosis. Incubation with the thromboxane synthase inhibitor, dazoxiben, caused a significant inhibition of vascular TxB2 synthesis and a significant increase in 6-keto-PGFlα synthesis. In 3 of the 5 cases the increase in 6-keto-PGFlα was too large to be explained by the fall in TxB2.