Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies.
Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies.
复制标题
小鼠抗狂犬病单克隆抗体在狂犬病暴露后治疗中的应用。
DOI：
10.1172/jci114260
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Koprowski,H
中科院分区：
文献类型：
--
作者：
Schumacher,CL;Dietzschold,B;Ertl,HC;Niu,HS;Rupprecht,CE;Koprowski,H
用狂犬病病毒核衣壳蛋白和糖蛋白特异性小鼠单克隆抗体的混合物免疫小鼠和仓鼠，不仅在免疫后用致死剂量的狂犬病病毒攻击时保护动物，而且在暴露后的情况下也保护动物。病毒接种后3 h用MAb混合物处理的仓鼠完全免受致死性狂犬病病毒感染，病毒攻击后36 h给予MAb混合物时，80%的动物存活。这种单克隆抗体鸡尾酒的潜在用途的人狂犬病的治疗后的external。
Immunization of mice and hamsters with a cocktail of mouse MAbs specific for rabies virus nucleocapsid protein and glycoprotein protected animals not only when challenged with a lethal dose of rabies virus after immunization, but also in post-exposure situations. Hamsters treated with the MAb cocktail 3 h after virus inoculation were completely protected from lethal rabies virus infection, and 80% of the animals survived when the MAb cocktail was given 36 h after virus challenge. The potential usefulness of this MAb cocktail for the postexposure treatment of human rabies is discussed.