Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers.
Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers.
复制标题
年龄对患有或不患有创伤后应激障碍的抑郁症患者以及健康志愿者的皮质醇水平的影响。
DOI：
10.1016/j.jad.2003.09.012
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发表时间：
2004
影响因子：
6.6
通讯作者：
Mann,JJohn
中科院分区：
文献类型：
--
作者：
Sher,Leo;Oquendo,MariaA;Galfalvy,HangaC;Cooper,ThomasB;Mann,JJohn
背景创伤后应激障碍（PTSD）和重性抑郁症经常共病。年龄和重性抑郁症与较高的皮质醇水平和地塞米松抵抗相关，而PTSD与较低的皮质醇和地塞米松超敏性相关。因此，我们研究了年龄的影响下丘脑-垂体-肾上腺（HPA）系统的抑郁症患者和无PTSD.Methods31例抑郁症患者没有PTSD，12例抑郁症患者PTSD，和23名健康志愿者进行了研究2天。受试者在第1天接受单盲安慰剂，在第2天接受芬氟拉明。皮质醇水平在挑战之前，并为5 h after.ResultsCortisol水平随着年龄的增长而增加，在抑郁症患者没有PTSD，但在抑郁症患者PTSD或健康志愿者。以前的严重抑郁症发作的数量是预测皮质醇对芬氟拉明管理的抑郁症患者没有PTSD.ConclusionsThe结果，我们的研究强调了考虑年龄在心理生物学的重要性。需要进一步的研究来充分描述年龄在重度抑郁症和创伤后应激障碍中发现的HPA轴异常中的作用。
BackgroundPost-traumatic stress disorder (PTSD) and major depression are frequently comorbid. Age and major depression are associated with higher cortisol levels and dexamethasone resistance, whereas PTSD is associated with lower cortisol and dexamethasone supersensitivity. Therefore, we examined the effect of age on the hypothalamic–pituitary–adrenal (HPA) system in depressed patients with and without PTSD.MethodsThirty-one depressed patients without PTSD, 12 depressed patients with PTSD, and 23 healthy volunteers were studied on 2 days. Subjects received single-blind placebo on day 1 and fenfluramine on day 2. Cortisol levels were drawn before challenge and for 5 h thereafter.ResultsCortisol levels increase with age in depressed patients without PTSD but not in depressed patients with PTSD or in healthy volunteers. Number of previous major depressive episodes was a predictor of the cortisol response to fenfluramine administration in depressed patients without PTSD.ConclusionsThe results of our study highlight the importance of considering age in psychobiology. Further research is needed to fully delineate the role of age in abnormalities of the HPA axis found in major depression and PTSD.