Cellulose-based molecularly imprinted red-blood-cell-like microparticles for the selective capture of cortisol
Cellulose-based molecularly imprinted red-blood-cell-like microparticles for the selective capture of cortisol
复制标题
DOI：
10.1016/j.carbpol.2018.03.095
复制
发表时间：
2018-08-01
影响因子：
11.2
通讯作者：
Yogo, Toshinobu
中科院分区：
文献类型：
--
作者：
Hayashi, Koichiro;Hayashi, Hikaru;Yogo, Toshinobu
采用分子印迹乙基纤维素（EHEC）前体电喷雾技术合成了含有红细胞样微粒（M-RBC-MPs）的磁铁矿纳米颗粒，该颗粒具有选择性捕获皮质醇（COR）的能力。合成的M-RBC-MPs类似于3 μ m-磁盘，但有凹痕。M-RBC-MPs含有直径小于15 nm的磁铁矿纳米颗粒，具有一定的磁化性能，且无室温矫顽力。分子印迹的M-RBC-MPs （MI-M-RBC-MPs）通过小于其直径的孔。MI-M-RBC-MPs选择性地从含有类似COR分子的溶液中捕获COR，而非印迹的M-RBC-MPs不能捕获COR。此外，磁铁用于捕获在管中流动的水分散的MI-M-RBC-MPs。基于上述结果，MI-M-RBC-MPs可以选择性地捕获COR，同时在血液中循环，然后使用磁铁将其从血液中去除。
Magnetite-nanoparticle-containing red-blood-cell-like-microparticles (M-RBC-MPs) with a selective ability for trapping cortisol (COR) were synthesized by an electrospray technique of a molecularly imprinted ethyl(hydroxyethyl) cellulose (EHEC)-based precursor. The as-synthezied M-RBC-MPs were similar to 3-mu m-disks with a dent. M-RBC-MPs contained magnetite nanoparticles below 15 nm in diameter, which exhibited magnetization and no room-temperature coercivity. The molecularly imprinted M-RBC-MPs (MI-M-RBC-MPs) passed through pores less than their diameter. The MI-M-RBC-MPs selectively trapped COR from a solution containing molecules similar to COR, whereas non-imprinted M-RBC-MPs did not trap COR. Furthermore, magnets were used to capture the water-dispersed MI-M-RBC-MPs flowing in a tube. Based on the above results, MI-M-RBC-MPs may selectively trap COR while simultaneously circulating in the blood, followed by their removal from the blood using magnets.