The increases in rat cortical and midbrain tryptophan hydroxylase activity in response to acute or repeated sound stress are blocked by bilateral lesions to the central nucleus of the amygdala.
The increases in rat cortical and midbrain tryptophan hydroxylase activity in response to acute or repeated sound stress are blocked by bilateral lesions to the central nucleus of the amygdala.
复制标题
大鼠皮质和中脑色氨酸羟化酶活性因急性或重复的声音应激而增加，但被杏仁核中央核的双侧损伤所阻断。
DOI：
10.1016/0006-8993(90)90656-v
复制
发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Boadle-Biber,MC
中科院分区：
文献类型：
--
作者：
Singh,VB;Onaivi,ES;Phan,TH;Boadle-Biber,MC
声应激（120分贝脉冲，持续100毫秒，每分钟1小时）可使雄性sd大鼠体外皮质或中脑色氨酸羟化酶活性升高，而体外用碱性磷酸酶孵育酶制剂可消除这种活性。连续3次（前2次间隔24 h，第2次和第3次间隔48 h），体外酶活性稳定提高，不受碱性磷酸酶的影响。杏仁核中央核的双侧病变阻断了急性和重复SS所获得的酶活性的增加，但假应激大鼠的酶活性不受影响。
Sound stress (SS) (120-dB pulses of 100 ms duration, every min for 1 h) produces an elevation of in vitro cortical or midbrain tryptophan hydroxylase activity from male Sprague-Dawley rats that is abolished, in vitro, by incubation of the enzyme preparation with alkaline phosphatase. SS, when repeated on 3 different occasions, the first 2 sessions 24 h apart and the 2nd and 3rd session separated by 48 h, produces a stable increase in the in vitro enzyme activity that is unaffected by alkaline phosphatase. Bilateral lesions to the central nucleus of the amygdala block both increases in enzyme activity obtained in response to acute and repeated SS, but leave enzyme activity from sham-stressed rats unaffected.