Rapid formation and remodeling of postsynaptic densities in developing dendrites
Rapid formation and remodeling of postsynaptic densities in developing dendrites
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DOI：
10.1038/nn717
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发表时间：
2001-10-01
影响因子：
25
通讯作者：
Dailey, ME
中科院分区：
文献类型：
--
作者：
Marrs, GS;Green, SH;Dailey, ME
本实验在海马脑片上观察了突触后致密物（PSD）形成和重构的动态变化。表达GFP标记的PSD 95（一种重要的PSD蛋白）的转染神经元的延时成像显示，发育中树突中高达40%的PSD是结构动态的;它们迅速（
The dynamics of postsynaptic density (PSD) formation and remodeling were investigated in live developing hippocampal tissue slices. Time lapse imaging of transfected neurons expressing GFP-tagged PSD95, a prominent PSD protein, revealed that up to 40% of PSDs in developing dendrites are structurally dynamic; they rapidly (