Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's
Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's
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DOI：
10.1016/j.jalz.2019.09.004
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发表时间：
2020-04-01
影响因子：
14
通讯作者：
Kramer, Joel H.
中科院分区：
文献类型：
--
作者：
Elahi, Fanny M.;Casaletto, Kaitlin B.;Kramer, Joel H.
简介：我们研究了散发性早发性和晚发性阿尔茨海默病患者的星形细胞病变、脑变性、可塑性和炎症的血浆蛋白质组学标志物方法：采用超灵敏免疫测定法对33例EOAD、30例LOAD和36例功能正常老年人的血浆进行分析。营养性（BDNF、VEGF、TGF β）、变性性（GFAP、NfL）和炎性（TNF α、IL-6、IP-10、IL-10）。营养因子在两个AD组中均升高，并与认知和灰质体积相关。EOAD组的退行性因子升高，且该组中退行性因子水平越高，功能越差。炎症的生物标志物没有显着不同的群体之间，只与again. Dissusssion：血浆蛋白质组生物标志物提供了新的手段，调查在体内的分子过程及其对临床结果的贡献。我们目前的初步调查，这些液体生物标志物，捕捉方面的星形细胞病变，神经元损伤，细胞可塑性，炎症EOAD与负载。
Introduction: We investigated plasma proteomic markers of astrocytopathy, brain degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset Alzheimer's disease (EOAD and LOAD).Methods: Plasma was analyzed using ultra-sensitive immuno-based assays from 33 EOAD, 30 LOAD, and 36 functionally normal older adults.Results: Principle component analyses identified 3 factors: trophic (BDNF, VEGF, TGF beta), degenerative (GFAP, NfL), and inflammatory (TNF alpha, IL-6, IP-10, IL-10). Trophic factor was elevated in both AD groups and associated with cognition and gray matter volumes. Degenerative factor was elevated in EOAD, with higher levels associated with worse functioning in this group. Biomarkers of inflammation were not significantly different between groups and were only associated with age.Disucssion: Plasma proteomic biomarkers provide novel means of investigating molecular processes in vivo and their contributions to clinical outcomes. We present initial investigations of several of these fluid biomarkers, capturing aspects of astrocytopathy, neuronal injury, cellular plasticity, and inflammation in EOAD versus LOAD.