Antimycobacterial Efficacy of Andrographis paniculata Leaf Extracts Under Intracellular and Hypoxic Conditions
Antimycobacterial Efficacy of Andrographis paniculata Leaf Extracts Under Intracellular and Hypoxic Conditions
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DOI：
10.1177/2156587214553303
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发表时间：
2015-01-01
影响因子：
3.5
通讯作者：
Birdi, Tannaz
中科院分区：
文献类型：
--
作者：
Bhatter, Purva;Gupta, Pooja;Birdi, Tannaz
在细胞内和无菌缺氧条件下，研究了穿心莲提取物对结核分枝杆菌生长的抑制作用。这种抑制作用(用金标准菌落形成单位实验证实)随着提取物浓度的增加而增强。有机溶剂提取物在无菌和胞内模拟的微好氧条件下对细菌生长的抑制作用强于水提取物。这一点可以进一步探索，以评估该植物用于抗非复制/休眠细菌的潜力。
The inhibition of the growth of Mycobacterium tuberculosis by the extracts of Andrographis paniculata has been studied using intracellular and axenic hypoxic conditions. The inhibition (confirmed using the gold standard colony forming unit assay) was found to increase with "double stimuli'' or higher concentration of the extract. Organic solvent extracts were found to inhibit bacterial growth more than the aqueous extracts under microaerophilic conditions mimicked through axenic and intracellular assays. This could be further explored to evaluate the potential of the plant to be used against nonreplicating/dormant bacilli.