Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region
Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region
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DOI：
10.1002/anie.201612301
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发表时间：
2017-03-06
影响因子：
16.6
通讯作者：
Yang, Youjun
中科院分区：
文献类型：
--
作者：
Lei, Zuhai;Li, Xinran;Yang, Youjun
在800-950 nm区域具有光谱活性的小分子有机荧光团因其在生物医学和材料应用中的广泛潜力而受到追捧。我们已经开发了一种新的明亮荧光染料（ECX）家族来应对这一挑战。ECX染料对可见光区是透明的，而在近红外区在约880 nm处有强吸收。它们在915 nm附近发射，荧光量子产率高达13.3%。ECX染料表现出高化学稳定性、高光稳定性和低聚集倾向。ECX染料的其他优点包括低程度的溶剂化显色性和容易的合成后衍生化。ECX染料有可能使800-950 nm区域可用于光谱和显微应用，并且也有望找到广泛的材料应用。
Small-molecule organic fluorophores spectrally active in the 800-950 nm region are sought-after for their broad potential in biomedical and material applications. We have developed a new family of brightly fluorescent dyes (ECX) to meet this challenge. ECX dyes are transparent to the visible region, while strongly absorbing in the NIR region at approximately 880 nm. They emit at around 915 nm with a fluorescence quantum yield up to 13.3%. ECX dyes exhibit high chemostability, high photostability, and low tendency to aggregate. Other merits of ECX dyes include low degree of solvatochromism and facile post-synthetic derivatization. ECX dyes potentially make available the 800-950 nm region for spectroscopic and microscopic applications and are also expected to find broad material applications.