Chemistry. Expanding the scope of fluorine tags for PET imaging.
Chemistry. Expanding the scope of fluorine tags for PET imaging.
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化学。
DOI：
10.1126/science.1245011
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kung,HankF
中科院分区：
文献类型：
--
作者：
Zhu,Lin;Ploessl,Karl;Kung,HankF
每年有数百万患者接受PET（正电子发射断层扫描）成像，但对能够诊断和监测多种疾病的新型PET成像探头的需求尚未得到满足。用于PET成像的最通用的放射性核素之一是18F，但是基于18F的任何探针的快速化学合成是必不可少的，因为其物理半衰期仅为110分钟。Huibanet al.最近报道了用18F标记三氟甲基芳烃（Ar-CF 3）的改进方法，该方法可以极大地促进新PET探针的开发和采用，并且允许鉴定现有药物的作用位点。
Millions of patients undergo PET (positron emission tomography) imaging every year, but there is a critical unmet need for new PET imaging probes capable of diagnosing and monitoring a multitude of diseases. One of the most versatile radionuclides for PET imaging is18F, but rapid chemical synthesis of any probe based on18F is essential because its physical half-life is only 110 min. Huibanet al.recently reported an improved method for labeling trifluoromethylarenes (Ar-CF3) with18F that could greatly facilitate the development and adoption of new PET probes and allow the site of action of existing drugs to be identified.