DEVELOPMENTAL-CHANGES IN BRAIN METABOLISM IN SEDATED RHESUS MACAQUES AND VERVET MONKEYS REVEALED BY POSITRON EMISSION TOMOGRAPHY
DEVELOPMENTAL-CHANGES IN BRAIN METABOLISM IN SEDATED RHESUS MACAQUES AND VERVET MONKEYS REVEALED BY POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1093/cercor/5.3.222
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发表时间：
1995-05-01
期刊：
影响因子：
3.7
通讯作者：
RALEIGH, MJ
中科院分区：
文献类型：
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作者：
JACOBS, B;CHUGANI, HT;RALEIGH, MJ
目前的正电子发射断层扫描研究使用 2-脱氧-2[F-18]氟-D-葡萄糖来检查镇静恒河猴和黑长尾猴局部大脑葡萄糖代谢率 (LCMRglc) 与年龄相关的变化。以横断面设计扫描了 19 只黑长尾猴，其中包括三个年龄组（出生至 59 天、60-179 天、180 天）到成人），捕获了第二组内最大突触密度的发育时期。还对两只恒河猴和两只黑长尾猴进行了纵向检查，受试者在整个过程中使用氯胺酮和咪达唑仑组合进行镇静，对 20 个脑区的纵向和横断面分析表明恒河猴和黑长尾猴的 LCMRglc 最低
The present positron emission tomography study used 2-deoxy-2[F-18]fluoro-D-glucose to examine age-related changes in local cerebral metabolic rates for glucose (LCMRglc) in sedated rhesus macaques and vervet monkeys, Nineteen vervet monkeys were scanned in a cross-sectional design, which consisted of three age groups (birth to 59 d, 60-179 d, 180 d to adult) that captured the developmental period of greatest synaptic density within the second group. Two rhesus and two vervet monkeys were also examined longitudinally, Subjects were sedated throughout the procedure with a combination of ketamine and midazolam, Longitudinal and cross-sectional analyses of 20 brain regions indicated lowest LCMRglc in rhesus and vervet monkeys