Surface ligand coordination induced self-assembly of a nanohybrid for efficient photodynamic therapy and imaging
Surface ligand coordination induced self-assembly of a nanohybrid for efficient photodynamic therapy and imaging
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DOI：
10.1039/c8qi00777b
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发表时间：
2018-10
影响因子：
7
通讯作者：
Pingru Su;Zhanwu Zhu;Qi-Meng Fan;Jing Cao;Yue-Ping Wang;Xiaoxi Yang;Bo Cheng;Weisheng Liu
中科院分区：
文献类型：
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作者：
Pingru Su;Zhanwu Zhu;Qi-Meng Fan;Jing Cao;Yue-Ping Wang;Xiaoxi Yang;Bo Cheng;Weisheng Liu
纳米杂化材料极大地促进了纳米材料在现实世界问题中的应用，因为它们不仅呈现出每种材料各自的先进性能，而且还可以实现组合材料功能的放大。在这里，我们使用聚丙烯酸（PAA）作为表面桥联剂通过直接配位将上转换纳米粒子NaYF4、Yb/Er@NaYF4（UCNP）和MnFe2O4（MF）组装成多功能纳米杂化物。然后，将光敏剂分子玫瑰红（RB）和PEG-COOH共价接枝到纳米杂化物上。 UCNPs通过荧光共振能量转移效应有效刺激RB，将O2转化为1O2。同时，MF NPs作为芬顿催化剂，在H2O2过表达的肿瘤微环境中通过分解H2O2持续产生O2。由此，成功构建了一个综合治疗系统，可以在980 nm激光的激发下有效地对缺氧肿瘤进行光动力治疗（PDT）。这项工作探索了一种使用异质纳米材料通过与纳米粒子之间的桥接配体协调来组装纳米杂化物的新方法，并为缺氧肿瘤提供了一种多功能的 PDT 候选方案。
Nanohybrids have greatly promoted the application of nanomaterials in real world problems, since they not only present the individual advanced properties of each material, but can also realize the amplification of the functions of the combined materials. Here, we assembled up-conversion nanoparticles NaYF4,Yb/Er@NaYF4 (UCNPs) and MnFe2O4 (MF) into a multi-functional nanohybrid through direct coordination using polyacrylic acid (PAA) as the surficial bridging linker. Afterwards, the photosensitizer molecules Rose Bengal (RB) and PEG-COOH were covalently grafted onto the nanohybrid. UCNPs effectively stimulated RB by means of fluorescence resonance energy transfer effects to convert O2 to 1O2. Meanwhile, the MF NPs worked as a Fenton catalyst to continuously generate O2 by decomposing H2O2 in the H2O2 over-expression tumor micro-environment. Thus, a comprehensive therapeutic system was successfully constructed, which can efficiently perform photodynamic therapy (PDT) of hypoxic tumors under the excitation of a 980 nm laser. This work explored a new method for the assembly of nanohybrids using heterogeneous nanomaterials by coordination with bridging ligands between NPs and provided a versatile PDT candidate for hypoxic tumors.