Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix.
Variants in human papillomavirus receptor and associated genes are associated with type-specific HPV infection and lesion progression of the cervix.
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人乳头瘤病毒受体和相关基因的变异与特定型HPV感染和宫颈病变进展有关
DOI：
10.18632/oncotarget.9510
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发表时间：
2016-06-28
期刊：
影响因子：
--
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Zou J;Cao Z;Zhang J;Chen T;Yang S;Huang Y;Hong D;Li Y;Chen X;Wang X;Cheng X;Lu W;Xie X
人乳头瘤病毒（HPV）通过细胞膜受体感染宫颈上皮细胞，进而诱发宫颈癌的发生和进展。单核苷酸多态性（SNP）可能会影响疾病的易感性和结果，但目前尚不清楚HPV受体和相关基因的变异是否与特定型HPV感染和宫颈病变进展有关。我们通过Illumina BeadXpress VeraCode平台对3299份宫颈脱落细胞样本中的875份HPV阴性或单一HPV16、18、52、58阳性样本中的8个基因中可能参与HPV感染过程的96个SNP进行了检测，并分析了SNP与特定类型HPV感染和宫颈病变进展之间的相关性。我们发现EGFR中的rs28384376和HSPG2中的rs12034979与HPV16感染显着相关； SDC2中的rs2575738、rs2575712、rs2575735和HSPG2中的rs6697265与HPV18感染显着相关； FGFR2中的rs10510097、EGFR中的rs12718946与HPV52感染显着相关； EGFR中的rs4947972、FGFR2中的rs2981451、SDC2中的rs2575735与HPV58感染显着相关。且FGFR2中的rs3135772、rs1047057和rs2556537、HSPG2中的rs12034979、SDC2中的rs16894821与HPV16感染诱发的宫颈病变进展显着相关； HPV18感染导致HSPG2中的rs6697265和rs6680566，ITGA6中的rs16860426； HPV52感染导致HSPG2中的rs878949、EGFR中的rs12718946和rs12668175； HPV58 感染无 SNP。我们的研究结果表明，HPV受体和相关基因变异可能影响HPV特异性感染的易感性和宫颈病变进展，这可能在宫颈癌筛查和治疗中具有潜在的应用价值。
Human papillomavirus (HPV) infects cervical epithelial cells through cellular membrane receptors, and then induces the initiation and progression of cervical cancer. Single nucleotide polymorphisms (SNPs) may impact the susceptibility and outcome of diseases, but it's still unknown whether variant in HPV receptor and associated genes is associated with type-specific HPV infection and cervical lesion progression. We examined 96 SNPs in 8 genes which may participate in the HPV infection process in 875 samples with HPV negative or single HPV16, 18, 52, 58 positive from 3299 cervical exfoliated cell samples, by Illumina BeadXpress VeraCode platform, and analyzed the correlation between the SNPs and type-specific HPV infection and cervical lesions progression. We found rs28384376 in EGFR and rs12034979 in HSPG2 significantly correlated to HPV16 infection; rs2575738, rs2575712, rs2575735 in SDC2 and rs6697265 in HSPG2 significantly correlated to HPV18 infection; rs10510097 in FGFR2, rs12718946 in EGFR significantly correlated to HPV52 infection; rs4947972 in EGFR, rs2981451 in FGFR2, rs2575735 in SDC2 significantly correlated to HPV58 infection. And rs3135772, rs1047057 and rs2556537 in FGFR2, rs12034979 in HSPG2, rs16894821 in SDC2 significantly correlated to cervical lesion progression induced by HPV16 infection; rs6697265 and rs6680566 in HSPG2, rs16860426 in ITGA6 by HPV18 infection; rs878949 in HSPG2, rs12718946 and rs12668175 in EGFR by HPV52 infection; no SNP by HPV58 infection. Our findings suggest that HPV receptor and associated gene variants may influence the susceptibilities to HPV type-specific infection and cervical lesion progression, which might have a potential application value in cervical cancer screening and therapy.
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影响因子：
51.1
作者：
de Sanjose, Silvia;Quint, Wim G. V.;Xavier Bosch, F.
通讯作者：
Xavier Bosch, F.
DOI：
10.1159/000355959
发表时间：
2014-01-01
期刊：
HUMAN PAPILLOMAVIRUS: BENCH TO BEDSIDE
影响因子：
--
作者：
Nguyen, Harrison P.;Ramirez-Fort, Marigdalia K.;Rady, Peter L.
通讯作者：
Rady, Peter L.
影响因子：
5.4
作者：
Richards, Kathleen F.;Bienkowska-Haba, Malgorzata;Sapp, Martin
通讯作者：
Sapp, Martin
影响因子：
4.8
作者：
Letian T;Tianyu Z
通讯作者：
Tianyu Z
影响因子：
3.4
作者：
Klasse PJ
通讯作者：
Klasse PJ