A double alkylation - ring closing metathesis approach to spiroimines
A double alkylation - ring closing metathesis approach to spiroimines
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DOI：
10.1016/j.tet.2004.04.059
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发表时间：
2004-06-21
期刊：
影响因子：
2.1
通讯作者：
Trzoss, M
中科院分区：
文献类型：
--
作者：
Brimble, MA;Trzoss, M
作为针对海洋毒素、螺环内酯和裸二胺合成计划的一部分，已经开发了关键双环螺环亚胺环系统的便捷合成方法。该方法涉及简单内酰胺的双烷基化、所得二烷基化内酰胺的格鲁布斯闭环复分解，然后将内酰胺还原成亚胺。 (C) 2004 Elsevier Ltd. 保留所有权利。
As part of a programme directed towards the synthesis of the marine toxins, the spirolides and gymnodimine, a convenient synthesis of the key bicyclic spiroimine ring systems has been developed. The method involves double alkylation of a simple lactam, Grubbs ring closing metathesis of the resultant dialkylated lactam then reduction of the lactam to an imine. (C) 2004 Elsevier Ltd. All rights reserved.