The Effect of Flecainide Acetate, a New Antiarrhythmic, on Plasma Digoxin Levels
The Effect of Flecainide Acetate, a New Antiarrhythmic, on Plasma Digoxin Levels
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新型抗心律失常药氟卡尼醋酸酯对血浆地高辛水平的影响
DOI：
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发表时间：
1986
影响因子：
2.9
通讯作者：
G. Lewis
中科院分区：
文献类型：
--
作者：
C. Weeks;G. J. Conard;D. Kvam;J. Fox;S. F. Chang;R. Paone;G. Lewis
在15名健康男性中评估口服醋酸氟氯胺对稳定地高辛水平的可能影响。每位志愿者连续22天每天（上午8点）服用地高辛0.25毫克，在第11至15天每天（上午8点和晚上8点）服用氟氯胺200毫克。用放射免疫法和气液相色谱法分别测定血浆地高辛和氟氯胺水平。氟氯胺水平在与患者室性早搏抑制相关的范围内。第9天和第10天（基线）上午8点前的平均血浆地高辛水平为0.46 ng/mL，第13天为0.57 ng/mL (P < 0.05)，第15天为0.49 ng/mL（无统计学意义[NS]）。与给药后6小时平均基线地高辛水平0.58 ng/mL相比，第13天和第15天的给药后水平分别为0.62 ng/mL和0.65 ng/mL （P < 0.05）。平均而言，每位受试者在给药前和给药后6小时地高辛水平分别增加了24±35%和13±19%。同时给药期间发生的心电图间期和生命体征的变化没有临床意义，尽管在一些受试者中发现了PR间期的轻微延长。除非血浆地高辛水平在治疗范围的上端，否则本研究中观察到的幅度变化对大多数患者来说在临床上是无关紧要的。
The possible effect of oral flecainide acetate on steady‐state digoxin levels was assessed in 15 healthy men. Each volunteer received digoxin 0.25 mg daily (8 am) for 22 consecutive days and flecainide 200 mg bid (8 am and 8 pm) on days 11 through 15. Plasma digoxin and flecainide levels were measured by radioimmunoassay and gas‐liquid chromatography methods, respectively. Flecainide levels were within the range associated with suppression of premature ventricular contractions in patients. Mean plasma digoxin levels just before the 8 am dose were 0.46 ng/mL on days 9 and 10 (baseline), 0.57 ng/mL (P < .05) on day 13, and 0.49 ng/mL (not significant [NS]) on day 15. Compared with a mean six‐hour postdose baseline digoxin level of 0.58 ng/mL, postdose levels were 0.62 ng/mL (NS) and 0.65 ng/mL (P < .05) on days 13 and 15, respectively. On an average for each subject, predose and six‐hour postdose digoxin levels increased by 24 ± 35% and 13 ± 19%, respectively, during coadministration. The changes in electrocardiographic intervals and vital signs that occurred during concomitant drug administration were not clinically significant although a slight prolongation of the PR interval was noted in some subjects. Unless plasma digoxin levels are in the upper end of the therapeutic range, changes in magnitude as observed in this study should be clinically inconsequential for most patients.
每日两次服用氟卡尼可抑制难治性室性心律失常。
DOI：
10.1016/0002-9149(81)90331-3
发表时间：
1981
期刊：
The American journal of cardiology
影响因子：
--
作者：
Duff,HJ;Roden,DM;Maffucci,RJ;Vesper,BS;Conard,GJ;Higgins,SB;Oates,JA;Smith,RF;Woosley,RL
通讯作者：
Woosley,RL