Implication of Sarcopenia and Sarcopenic Obesity on Lung Function in Healthy Elderly: Using Korean National Health and Nutrition Examination Survey.
Implication of Sarcopenia and Sarcopenic Obesity on Lung Function in Healthy Elderly: Using Korean National Health and Nutrition Examination Survey.
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DOI：
10.3346/jkms.2015.30.11.1682
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发表时间：
2015-11
影响因子：
4.5
通讯作者：
Kim HJ
中科院分区：
文献类型：
--
作者：
Moon JH;Kong MH;Kim HJ
以前的研究已经证明肥胖和肺功能下降之间存在正相关。然而，肌肉和脂肪的影响尚未得到充分评估，特别是在健康的老年人群中。在这项研究中，我们评估了低肌肉质量（LMM）和LMM合并肥胖对健康老年受试者肺功能损害的影响。我们的研究使用了2008年至2011年韩国国民健康和营养检查调查的数据。包括65岁或以上的男性和女性。双能X线吸收法测量肌肉质量。LMM定义为低于年轻健康成人性别特异性平均值的两个标准差。肥胖定义为体重指数≥ 25 kg/m2。65岁以上人群中LMM的患病率为11.9%。在调整年龄、性别、体重指数、吸烟状况、饮酒量和运动频率后，LMM和肺功能（用力肺活量和1秒用力呼气量）独立相关。LMM伴肥胖也与肺功能下降有关。这项研究表明，LMM是65岁以上健康韩国男性和女性肺功能下降的独立危险因素。
Previous studies have demonstrated a positive association between obesity and decreased lung function. However, the effect of muscle and fat has not been fully assessed, especially in a healthy elderly population. In this study, we evaluated the impact of low muscle mass (LMM) and LMM with obesity on pulmonary impairment in healthy elderly subjects. Our study used data from the Korea National Health and Nutrition Examination Survey from 2008 to 2011. Men and women aged 65 yr or older were included. Muscle mass was measured by dual-energy X-ray absorptiometry. LMM was defined as two standard deviations below the sex-specific mean for young healthy adults. Obesity was defined as body mass index ≥ 25 kg/m2. The prevalence of LMM in individuals aged over 65 was 11.9%. LMM and pulmonary function (forced vital capacity and forced expiratory volume in 1 second) were independently associated after adjusting for age, sex, body mass index, smoking status, alcohol consumption, and frequency of exercise. LMM with obesity was also related to a decrease in pulmonary function. This study revealed that LMM is an independent risk factor of decreased pulmonary function in healthy Korean men and women over 65 yr of age.