MICROBUBBLE INJECTION ENHANCES INHIBITION OF LOW-INTENSITY PULSED ULTRASOUND ON DEBRIS-INDUCED PERIPROSTHETIC OSTEOLYSIS IN RABBIT MODEL
MICROBUBBLE INJECTION ENHANCES INHIBITION OF LOW-INTENSITY PULSED ULTRASOUND ON DEBRIS-INDUCED PERIPROSTHETIC OSTEOLYSIS IN RABBIT MODEL
复制标题
微泡注射增强了低强度脉冲超声对兔模型碎片引起的假体周围骨溶解的抑制作用。
DOI：
10.1016/j.ultrasmedbio.2014.08.016
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发表时间：
2015-01-01
影响因子：
2.9
通讯作者：
Yan, Shi-Gui
中科院分区：
文献类型：
--
作者：
Hu, Bin;Cai, Xun-Zi;Yan, Shi-Gui
We determined whether the addition of microbubbles enhances the effect of low-intensity pulsed ultrasound (LIPUS) on bone-implant integration in an early-stage osteolysis model. The bone canals were injected with titanium particles before implantation to establish the periprosthetic osteolysis model. Before ultrasonic therapy, the microbubble-enhanced LIPUS group (G(Ti-Us-Mb)) received an intra-articular injection of microbubbles. Biomechanical testing revealed that G(Ti-Us-Mb) had significantly greater fixation strength than the LIPUS group (G(Ti-Us)). Distal periprosthetic bone mineral density was also higher in G(Ti-Us) than in the Ti group (G(Ti)), but no significant increase was detected after administration of microbubbles. Histomorphometric analyses revealed that bone formation around the implant in G(Ti-Us) was enhanced by the addition of microbubbles in G(Ti-Us-Mb). Taken together, our data indicate that microbubble injection enhances the inhibitory effect of LIPUS on debrisinduced osteolysis and further strengthens the mechanical fixation of implants in an early-stage osteolysis model in vivo. (E-mail: jointsahzu@aliyun.com) (C) 2015 World Federation for Ultrasound in Medicine & Biology.
