Inferring simple but precise quantitative models of human oocyte and early embryo development.
Inferring simple but precise quantitative models of human oocyte and early embryo development.
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推断人类卵母细胞和早期胚胎发育的简单但精确的定量模型。
DOI：
10.1098/rsif.2021.0475
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Needleman,Daniel
中科院分区：
文献类型：
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作者：
Leahy,BrianD;Racowsky,Catherine;Needleman,Daniel
宏观的现象学模型是有用的，可以作为我们理解从统计物理到金融到生物学等领域的简明框架。构建发育的现象学模型将为理解卵子发生和胚胎发生的复杂性和调节性提供一个框架。在这里，我们使用数据驱动的方法来推断人类卵母细胞成熟和植入前胚胎发育的定量，精确模型，通过分析7399个IVF周期的临床体外受精（IVF）数据，产生57827个胚胎。令人惊讶的是，我们发现，卵母细胞成熟和早期胚胎发育定量描述的简单模型与最小的相互作用。这种简单性表明，卵子发生和胚胎发生是由模块化的过程，是相对孤立的。特别是，我们的分析提供了强有力的证据表明：（i）前腔卵泡产生抗苗勒管激素，独立于其他卵泡的影响，（ii）卵母细胞成熟至中期II，独立于女性的年龄，她的BMI和其他因素，（iii）早期胚胎发育对于这里评估的变量是无记忆的，因为胚胎从其当前发育阶段过渡到下一个发育阶段的概率与其先前阶段无关。我们的研究结果都提供了深入了解卵子发生和胚胎发生的基本原理，并对临床IVF具有指导意义。
Macroscopic, phenomenological models are useful as concise framings of our understandings in fields from statistical physics to finance to biology. Constructing a phenomenological model for development would provide a framework for understanding the complicated, regulatory nature of oogenesis and embryogenesis. Here, we use a data-driven approach to infer quantitative, precise models of human oocyte maturation and pre-implantation embryo development, by analysing clinicalin-vitrofertilization (IVF) data on 7399 IVF cycles resulting in 57 827 embryos. Surprisingly, we find that both oocyte maturation and early embryo development are quantitatively described by simple models with minimal interactions. This simplicity suggests that oogenesis and embryogenesis are composed of modular processes that are relatively siloed from one another. In particular, our analysis provides strong evidence that (i) pre-antral follicles produce anti-Müllerian hormone independently of effects from other follicles, (ii) oocytes mature to metaphase-II independently of the woman’s age, her BMI and other factors, (iii) early embryo development is memoryless for the variables assessed here, in that the probability of an embryo transitioning from its current developmental stage to the next is independent of its previous stage. Our results both provide insight into the fundamentals of oogenesis and embryogenesis and have implications for the clinical IVF.