Iron porphyrin-catalyzed olefination of ketenes with diazoacetate for the enantioselective synthesis of allenes
Iron porphyrin-catalyzed olefination of ketenes with diazoacetate for the enantioselective synthesis of allenes
复制标题
铁卟啉催化乙烯酮与重氮乙酸的烯化反应对映选择性合成丙二烯
DOI：
10.1021/ja068642v
复制
发表时间：
2007-02-14
影响因子：
15
通讯作者：
Dai, Li-Xin
中科院分区：
文献类型：
--
作者：
Li, Chuan-Ying;Wang, Xiao-Bing;Dai, Li-Xin
在ph3P和Fe(Tcp)Cl催化下，首次在中性条件下，烯类化合物与EDA反应高产率地生成了烯类化合物。用手性膦取代PPh3，可以以较高的对映选择性(93-98%ee)高产率地合成烯丙烯。
In the presence of Ph3P and catalytic Fe(TCP) Cl, ketenes could react with EDA to give allenes in high yields under neutral conditions for the first time. By employing chiral phosphine instead of PPh3, allenes could be synthesized with high enantioselectivity (93-98% ee) in good yields.