Glycosylation of hair: possible measure of chronic hyperglycaemia.
Glycosylation of hair: possible measure of chronic hyperglycaemia.
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头发的糖基化：慢性高血糖的可能措施。
DOI：
10.1136/bmj.288.6418.669
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. Hartog
中科院分区：
文献类型：
--
作者：
R. Paisey;J. Clamp;M. Kent;N. Light;M. Hopton;M. Hartog
为了确定糖尿病患者的头发是否过度糖基化，我们从50名白人非糖尿病患者和46名糖尿病患者的耳后近端取了4厘米的头发样本。通过对硫代巴比妥酸反应的修饰，测定了毛发糖基化。同时取糖尿病患者的血，测定糖化血红蛋白浓度。正常毛发中果糖胺（mumol/100 mg毛发）的平均（1 SD）浓度为0.054（0.011）。糖基化与性别、年龄或发色无关。糖尿病患者头发糖基化程度较正常人严重(0.097(0.045)，差异有统计学意义（p < 0.01）；糖尿病患者头发糖基化与糖化血红蛋白浓度存在相关性（r = 0.71, p < 0.01）。当与葡萄糖孵育时，非糖尿病患者的头发显示出稳定的与时间相关的糖基化增加。头发的糖基化可能提供一种稳定的长期的组织糖基化测量，有助于糖尿病微血管并发症的研究。
To determine whether hair is excessively glycosylated in diabetes mellitus 4 cm hair samples were taken proximally from behind the ear in 50 white non-diabetics and 46 diabetics. Hair glycosylation was assayed by a modification of the thiobarbituric acid reaction. Blood was taken from the diabetics at the same time for measurement of glycosylated haemoglobin concentration. The mean (1 SD) concentration of fructosamine (mumol/100 mg hair) was 0.054 (0.011) for normal hair. Glycosylation was not related to sex, age, or hair colour. The diabetics' hair was more heavily glycosylated (0.097 (0.045] than normal (p less than 0.01) and there was a correlation between hair glycosylation and the concentration of glycosylated haemoglobin in the diabetics (r = 0.71; p less than 0.01). Hair from non-diabetics showed a stable time related increase in glycosylation when incubated with glucose. Glycosylation of hair might provide a stable long term measure of tissue glycosylation, useful in the investigation of microvascular complications of diabetes mellitus.