Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation
Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation
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DOI：
10.1161/01.cir.97.23.2299
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发表时间：
1998-06-16
期刊：
影响因子：
37.8
通讯作者：
Yasue, H
中科院分区：
文献类型：
--
作者：
Kugiyama, K;Ohgushi, M;Yasue, H
背景-氧自由基已被证明可引起内皮血管功能障碍。本研究检测了抗氧化剂还原型谷胱甘肽（GSH）对人冠状动脉循环的影响。方法和结果-冠状动脉内灌注乙酰胆碱对左前降支冠状动脉心外膜直径和血流量的反应分别采用冠状动脉造影定量法和多普勒血流导丝技术测定ACh（50 μ g/min），在26名无明显冠状动脉狭窄的受试者中，在联合冠状动脉内输注GSH（50 mg/min）或生理盐水之前和期间。GSH可抑制ACh引起的心外膜收缩反应，增强ACh引起的心外膜血流增加反应，并增强硝酸甘油的扩冠作用。GSH对ACh心外膜直径反应的有益作用在具有大于或等于1个冠状动脉危险因素的受试者亚组中观察到，但在没有危险因素的亚组中未观察到。盐水输注没有任何effects. Conclusions结果表明，GSH改善冠状动脉内皮血管功能，特别是在冠心病危险因素的受试者，它增强了硝酸甘油在人体冠状动脉的血管扩张作用。
Background-Oxygen free radicals have been shown to cause endothelial vasomotor dysfunction, This study examined the effect of reduced glutathione (GSH), an antioxidant, on human coronary circulation,Methods and Results-Responses of epicardial diameter and blood flow of the left anterior descending coronary artery to intracoronary infusion of acetylcholine (ACh, 50 mu g/min) were measured by quantitative coronary angiography and Doppler flow-wire technique, respectively, before and during combined intracoronary infusion of GSH (50 mg/min) or saline in 26 subjects with no significant coronary stenosis. GSH infusion suppressed the constrictor response of epicardial diameter to ACh and enhanced the increase in blood flow response to ACh, Furthermore, GSH potentiated the coronary dilator effect of nitroglycerin. A beneficial effect of GSH on the epicardial diameter response to ACh was observed in a subgroup of subjects with greater than or equal to 1 coronary risk factors but not in a subgroup without risk factors. Saline infusion did not have any effects.Conclusions-The results indicate that GSH improved coronary endothelial vasomotor function, particularly in subjects with coronary risk factors, and it potentiated the vasodilator effect of nitroglycerin in human coronary arteries.