Influence of maternal and placental factors on newborn body composition
Influence of maternal and placental factors on newborn body composition
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DOI：
10.1111/jpc.14565
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发表时间：
2019-08-07
影响因子：
1.7
通讯作者：
Gordon, Adrienne
中科院分区：
文献类型：
--
作者：
Dissanayake, Hasthi U.;Anderson, Lyndal;Gordon, Adrienne
本研究的目的是评估母体特征、胎盘大小或组织学绒毛膜炎是否与新生儿身体成分相关。此外，我们试图确定胎盘重量是否可能介导母亲孕前体重和年龄与新生儿身体成分之间的关联。方法在澳大利亚悉尼的皇家阿尔弗雷德王子医院进行横断面研究。这项研究包括136名健康的单胎足月新生儿。招募按新生儿体脂百分比（性别和妊娠调整）分层。通过空气置换体积描记法评估体脂。由解剖病理学家进行胎盘检查。根据红线标准对母体（绒毛膜炎）和胎儿（绒毛膜和脐血管炎、脐带炎）炎症反应进行分类。结果孕妇孕前体重、产次、产程、胎盘重量和胎盘表面积与新生儿脂肪量和去脂肪量有关。妊娠期糖尿病和母亲年龄与新生儿脂肪质量相关，但与无脂肪质量无关。组织学绒毛膜炎和新生儿身体成分之间没有关联;然而，分娩的自发性发作与组织学绒毛膜炎的存在密切相关。只有25-31%的母亲体重和年龄与新生儿脂肪量的关联是通过胎盘介导的。结论母体因素与新生儿脂肪质量和去脂肪质量的相关性不同，提示控制脂肪质量和去脂肪质量的机制不同。我们的中介分析表明，胎盘重量部分介导的母亲因素与新生儿身体成分的关联。组织学绒毛膜炎与新生儿身体成分无关。
Aim The objective of this study was to assess whether maternal characteristics, placental size or histological chorioamnionitis was associated with newborn body composition. Furthermore, we sought to determine whether placental weight may mediate the association between maternal pre-pregnancy weight and age with newborn body composition. Methods A cross-sectional study was conducted at Royal Prince Alfred Hospital, Sydney, Australia. This study included 136 healthy, singleton, term-born newborns. Recruitment was stratified by newborn body fat percentiles (gender and gestational adjusted). Body fat was assessed by air displacement plethysmography. Placental examination was conducted by an anatomical pathologist. Maternal (chorioamnionitis) and fetal (chorionic and umbilical vasculitis, funisitis) inflammatory responses were classified according to Redline criteria. Results Maternal pre-pregnancy weight, parity, labour, placental weight and surface area were associated with newborn fat mass and fat-free mass. Gestational diabetes and maternal age were associated with newborn fat mass but not fat-free mass. There was no association between histological chorioamnionitis and newborn body composition; however, spontaneous onset of labour was strongly associated with the presence of histological chorioamnionitis. Only 25-31% of the association of maternal weight and age with newborn fat mass was mediated via the placenta. Conclusions Maternal factors associated with newborn fat mass and fat-free mass differed, indicating that different mechanisms control fat mass and fat-free mass. Our mediation analysis suggests that placental weight partly mediates the association of maternal factors with newborn body composition. Histological chorioamnionitis was not associated with newborn body composition.