Decoding Internally and Externally Driven Movement Plans
Decoding Internally and Externally Driven Movement Plans
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DOI：
10.1523/jneurosci.0596-15.2015
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发表时间：
2015-10-21
影响因子：
5.3
通讯作者：
Lingnau, Angelika
中科院分区：
文献类型：
--
作者：
Ariani, Giacomo;Wurm, Moritz F.;Lingnau, Angelika
在运动规划过程中，顶额叶网络内的大脑活动编码了关于即将到来的动作的信息，这些动作可以是外部驱动的（例如，通过感觉提示）或内部（即，选择/决定）。在这里，我们使用功能磁共振成像数据的多变量模式分析（MVPA）来区分代表（1）抽象运动计划的区域，这些计划概括了这些运动计划的驱动方式，（2）内部驱动的运动计划，或（3）外部驱动的运动计划。在延迟运动模式中，人类志愿者被要求计划和执行三种类型的非视觉引导的右手伸向中央目标物体的运动：使用精确抓握，力量抓握或触摸物体而无需手预塑形。在单独的试验块中，运动要么通过颜色线索（指示条件）指示，要么由参与者选择（自由选择条件）。使用基于ROI和基于全脑探照灯的MVPA，我们发现了计划运动的抽象表示，这些运动在顶叶皮层、背侧运动前皮层和对侧的初级运动皮层中的选择方式（内部与外部驱动）中进行概括。此外，我们揭示了特定的内部驱动的运动计划在对侧腹侧前运动皮层，背外侧前额叶皮层，缘上回，并在同侧后顶叶颞区，这表明这些地区的运动选择过程中招募。最后，我们观察到代表性的外部驱动的运动计划在双边补充运动皮层和类似的趋势，在presupplementary运动皮层，这表明在刺激反应映射的作用。
During movement planning, brain activity within parietofrontal networks encodes information about upcoming actions that can be driven either externally (e.g., by a sensory cue) or internally (i.e., by a choice/decision). Here we used multivariate pattern analysis (MVPA) of fMRI data to distinguish between areas that represent (1) abstract movement plans that generalize across the way in which these were driven, (2) internally driven movement plans, or (3) externally driven movement plans. In a delayed-movement paradigm, human volunteers were asked to plan and execute three types of nonvisually guided right-handed reaching movements toward a central target object: using a precision grip, a power grip, or touching the object without hand preshaping. On separate blocks of trials, movements were either instructed via color cues (Instructed condition), or chosen by the participant (Free-Choice condition). Using ROI-based and whole-brain searchlight-based MVPA, we found abstract representations of planned movements that generalize across the way these movements are selected (internally vs externally driven) in parietal cortex, dorsal premotor cortex, and primary motor cortex contralateral to the acting hand. In addition, we revealed representations specific for internally driven movement plans in contralateral ventral premotor cortex, dorsolateral prefrontal cortex, supramarginal gyrus, and in ipsilateral posterior parietotemporal regions, suggesting that these regions are recruited during movement selection. Finally, we observed representations of externally driven movement plans in bilateral supplementary motor cortex and a similar trend in presupplementary motor cortex, suggesting a role in stimulus-response mapping.