HIPPOCAMPAL-LESIONS DO NOT IMPAIR NEGATIVE PATTERNING - A CHALLENGE TO CONFIGURAL ASSOCIATION THEORY
HIPPOCAMPAL-LESIONS DO NOT IMPAIR NEGATIVE PATTERNING - A CHALLENGE TO CONFIGURAL ASSOCIATION THEORY
复制标题
DOI：
10.1037/0735-7044.107.2.227
复制
发表时间：
1993-04-01
影响因子：
1.9
通讯作者：
JARRARD, LE
中科院分区：
文献类型：
--
作者：
DAVIDSON, TL;MCKERNAN, MG;JARRARD, LE
根据构形关联（CAS）理论（Sutherland & Rudy，1989），大鼠需要完整的海马体来解决基于“构形”过程的学习问题。该理论将负面模式歧视视为此类问题的一个关键例子。 Rudy 和 Sutherland (1989) 报告称，颅内输注红藻氨酸 + 秋水仙碱 (KA + COL) 混合物会破坏海马结构损伤后的负性模式。我们评估了 KA + COL 造成海马损伤的大鼠与海马更具选择性的鹅膏酯损伤的大鼠相比的负性模式的获得。与对照组相比，两组均未表现出负面模式受损。转移测试提供的证据表明所有小组都使用配置流程来解决问题。因此，与 CAS 理论相反，海马体并不是构形过程运行的重要基质。
According to configural association (CAS) theory (Sutherland & Rudy, 1989), an intact hippocampus is required for rats to solve learning problems that are based on ''configural'' processes. This theory identifies the negative patterning discrimination as a critical example of this type of problem. Rudy and Sutherland (1989) reported disruption of negative patterning following hippocampal formation damage produced by intracranial infusion of a mixture of kainic acid + colchicine (KA + COL). We assessed acquisition of negative patterning in rats with hippocampal damage produced by KA + COL compared with rats with more selective ibotenate lesions of hippocampus. Neither group showed impaired negative patterning relative to controls. A transfer test provided evidence that all groups used configural processes to solve the problem. Thus contrary to CAS theory, the hippocampus is not an important substrate for the operation of configural processes.