Behavioral and neuronal investigations of hypervigilance in patients with fibromyalgia syndrome.
Behavioral and neuronal investigations of hypervigilance in patients with fibromyalgia syndrome.
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DOI：
10.1371/journal.pone.0035068
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ploner M
中科院分区：
文献类型：
--
作者：
Tiemann L;Schulz E;Winkelmann A;Ronel J;Henningsen P;Ploner M
疼痛刺激具有最大的行为相关性，从而影响注意力资源。在健康方面，疼痛对注意力的各种影响已经被观察到，表明疼痛的警觉和分散注意力的影响。在人脑中，这些效应与神经元伽马振荡的调制密切相关。由于过度警觉作为对外部刺激的异常注意力增加与慢性疼痛状态有关，我们假设纤维肌痛综合征（FMS）患者的注意力表现和疼痛诱导的伽马振荡都发生了改变。我们记录了脑电图从健康受试者（n = 22）和FMS患者（n = 19）在注意力要求视觉反应时间的任务。 在50%的试验中，我们使用了痛苦的激光刺激。自我评估问卷的结果证实，与健康对照组相比，FMS患者认为自己对疼痛高度警惕。然而，实验结果表明，疼痛刺激对注意力表现和神经元伽马振荡的影响在患者和健康受试者之间没有差异。我们进一步发现了一个显着的相关性之间的疼痛引起的调制视觉伽马振荡和疼痛引起的调制反应时间。这种关系在组间也没有差异。这些发现证实了伽马振荡和疼痛的可变注意力效应之间的密切关系，这在健康和疾病中似乎是可比的。因此，我们的研究结果并没有提供FMS患者的行为或神经元表现为过度警觉的证据。
Painful stimuli are of utmost behavioral relevance and thereby affect attentional resources. In health, variable effects of pain on attention have been observed, indicating alerting as well as distracting effects of pain. In the human brain, these effects are closely related to modulations of neuronal gamma oscillations. As hypervigilance as an abnormal increase of attention to external stimuli has been implicated in chronic pain states, we assumed both attentional performance and pain-induced gamma oscillations to be altered in patients with fibromyalgia syndrome (FMS). We recorded electroencephalography from healthy subjects (n = 22) and patients with FMS (n = 19) during an attention demanding visual reaction time task. In 50% of the trials we applied painful laser stimuli. The results of self-assessment questionnaires confirm that patients with FMS consider themselves hypervigilant towards pain as compared to healthy controls. However, the experimental findings indicate that the effects of painful stimuli on attentional performance and neuronal gamma oscillations do not differ between patients and healthy subjects. We further found a significant correlation between the pain-induced modulation of visual gamma oscillations and the pain-induced modulation of reaction times. This relationship did not differ between groups either. These findings confirm a close relationship between gamma oscillations and the variable attentional effects of pain, which appear to be comparable in health and disease. Thus, our results do not provide evidence for a behavioral or neuronal manifestation of hypervigilance in patients with FMS.
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影响因子：
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作者：
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