The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonates
The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonates
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DOI：
10.3174/ajnr.a0521
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发表时间：
2007-06-01
影响因子：
3.5
通讯作者：
Ferriero, D. M.
中科院分区：
文献类型：
--
作者：
Bartha, A. L.;Yap, K. R. L.;Ferriero, D. M.
背景和目的：新生儿早期缺乏规范的弥散张量成像 (DTI) 和 3D 磁共振波谱 (MRS) 数据。我们报告了一组健康足月新生儿的定量值，作为评估大脑发育和损伤的研究的基线数据。 材料和方法：在 1.5T 扫描仪上使用自旋回波 T1 和 T2 加权 MR 成像、DTI 和 3D 点分辨光谱序列 (PRESS) MRS 对 16 名健康足月新生儿（中位年龄，7 天）进行研究。通过 7 个脑区的自动处理计算平均扩散率 (D-av)、分数各向异性 (FA)、特征值 (EV) 和代谢物比率（N-乙酰天冬氨酸 [NAA]/胆碱、乳酸/胆碱）。通过盲法和验证的神经运动检查以及 3 个月和 14 个月时的 Bayley II 测试来评估神经发育。 结果：两名新生儿被排除在队列之外：一名新生儿在 T2 加权成像上有脑损伤，另一名 MR 成像正常，在 14 个月时表现出轻度认知延迟。其余 14 名新生儿的平均 DTI 值在以下范围之间：D-av = 0.98-1.48 10(-3) mm(2)/S，FA = 0.14-0.30，EV1 = 1.21-1.88，EV2 = 0.95-1.46，EV3 = 0.77-1.24（全部 X 10-3）毫米（2）/秒）。 NAA/胆碱比率范围在 0.58 至 0.73 之间，并且乳酸/胆碱最小（
BACKGROUND AND PURPOSE: There is a lack of normative diffusion tensor imaging (DTI) and 3D MR spectroscopy (MRS) data in the early neonatal period. We report quantitative values from a cohort of healthy term neonates to serve as baseline data for studies assessing brain development and injury.MATERIALS AND METHODS: Sixteen healthy term neonates (median age, 7 days) were studied with spin-echo T1- and T2-weighted MR imaging, DTI, and 3D point-resolved spectroscopy sequence (PRESS) MRS without sedation on a 1.5T scanner. Average diffusivity (D-av), fractional anisotropy (FA), eigenvalues (EV), and metabolite ratios (N-acetylaspartate [NAA]/choline, lactate/choline) were calculated by automated processing in 7 brain regions. Neurodevelopment was assessed by blinded and validated neuromotor examinations and the Bayley II test at 3 and 14 months.RESULTS: Two neonates were excluded from the cohort: one had brain injury on T2-weighted imaging, and the other, who had normal MR imaging, showed mildly delayed cognition at 14 months. The mean DTI values of the remaining 14 neonates were between these ranges: D-av = 0.98-1.48 10(-3) mm(2)/S, FA = 0.14-0.30, EV1 = 1.21-1.88, EV2 = 0.95-1.46, and EV3 = 0.77-1.24 (all X 10-3 mm(2)/s). The NAA/choline ratio ranged between 0.58 and 0.73, and minimal lactate/choline (