Construct validity of the RAND-12 and Health Utilities Index Mark 2 and 3 in type 2 diabetes
Construct validity of the RAND-12 and Health Utilities Index Mark 2 and 3 in type 2 diabetes
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DOI：
10.1023/b:qure.0000018497.06539.8f
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发表时间：
2004-03-01
影响因子：
3.5
通讯作者：
Johnson, JA
中科院分区：
文献类型：
--
作者：
Maddigan, SL;Feeny, DH;Johnson, JA
目的：评估 RAND-12 以及健康公用事业指数 Mark 2 (HUI2) 和 Mark 3 (HUI3) 在 2 型糖尿病中的横截面结构有效性。方法：使用参数检验来测试已知 2 型糖尿病组之间 HRQL 评分的差异，定义为治疗强度、糖尿病持续时间和血糖控制。结果：接受胰岛素治疗的个体的 RAND-12 的 PHC (40.28 +/- 10.97) 显着低于仅饮食治疗的个体 (45.18 +/- 12.02，p < 0.01)，MHC 也是如此 (42.83 +/- 10.75 vs. 46.87 +/- 10.89，p < 0.05)。对于糖尿病病程较长的患者，MHC（43.56 +/- 10.20 vs. 46.18 +/- 9.94，p < 0.05）和 PHC（41.04 +/- 10.64 vs. 45.62 +/- 10.48，p < 0.001）均较低。与糖尿病中位病程（5.0 年）以上的个体相比，病程较短的个体（0.60 +/- 0.29 对比 0.67 +/- 0.29，p < 0.01）以及使用胰岛素控制糖尿病的个体与单独饮食的个体相比（0.59 +/- 0.30 对比 0.69 +/- 0.30，p < 0.05），总体 HUI3 得分较低。疾病严重程度与 HUI3 的行走、灵活性和疼痛属性损伤相关。 HUI2 也发现了类似的结果。与使用胰岛素管理的个体相比，仅使用饮食管理的个体的总体 HUI2 得分最高。疾病严重程度与 HUI2 的活动能力和自我护理属性相关。未发现 HRQL 的任何测量值与血糖控制之间存在任何关系。结论：使用 RAND-12、HUI2 和 HUI3 进行的许多比较中，被认为患有更严重或晚期疾病的个体的评分显着较低。这项研究的结果为 HUI2、HUI3 和 RAND-12 在 2 型糖尿病中的构建有效性提供了证据。
Objective: To assess the cross-sectional construct validity of the RAND-12 and the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) in type 2 diabetes. Methods: Parametric tests were used to test for differences in HRQL scores between known groups with type 2 diabetes, defined in terms of treatment intensity, duration of diabetes and glycemic control. Results: The PHC of the RAND-12 was significantly lower for individuals treated with insulin (40.28 +/- 10.97) than diet alone (45.18 +/- 12.02, p < 0.01), as was the MHC (42.83 +/- 10.75 vs. 46.87 +/- 10.89, p < 0.05). MHC (43.56 +/- 10.20 vs. 46.18 +/- 9.94, p < 0.05) and PHC (41.04 +/- 10.64 vs. 45.62 +/- 10.48, p < 0.001) were both lower for those with longer duration of diabetes. Overall HUI3 scores were lower in individuals above the median duration of diabetes (5.0 years) as compared to those with a shorter duration (0.60 +/- 0.29 vs. 0.67 +/- 0.29, p < 0.01) and for individuals whose diabetes was managed using insulin compared to diet alone (0.59 +/- 0.30 vs. 0.69 +/- 0.30, p < 0.05). Disease severity was associated with impairment on the ambulation, dexterity and pain attributes of the HUI3. Similar results were found for the HUI2. Overall HUI2 scores were highest for individuals managed with diet alone compared to those managed with insulin. Disease severity was associated with the mobility and self-care attributes of the HUI2. No relationship was found between any of the measures of HRQL and glycemic control. Conclusions: Scores for individuals presumed to have more severe or advanced disease were significantly lower for many comparisons using the RAND-12, HUI2 and HUI3. The results of this study contribute evidence of construct validity of the HUI2, HUI3 and RAND-12 in type 2 diabetes.