Ovarian cancer: prevention, detection, and treatment of the disease and its recurrence. Molecular mechanisms and personalized medicine meeting report.
Ovarian cancer: prevention, detection, and treatment of the disease and its recurrence. Molecular mechanisms and personalized medicine meeting report.
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DOI：
10.1097/igc.0b013e31826bd1f2
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Edwards RP
中科院分区：
文献类型：
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作者：
Modugno F;Edwards RP
回顾目前对卵巢癌发生的分子、生物学和遗传学机制的认识，以及这些机制如何成为预防、检测和治疗卵巢癌及其复发的靶点。2012年5月，我们召集了一次研究人员、临床医生和消费者权益倡导者会议，审查了目前对分子机制的认识，并确定了进一步研究的富有成效的领域。会议包括七个科学会议，从流行病学，早期检测，生物学到治疗和生活质量。会议由卵巢癌研究领域的国际领导人的演讲和小组讨论组成。CDMRP国防部卵巢癌研究院的一个特别的职业发展会议以及一个口头摘要和海报会议展示了年轻科学家有前途的新研究。过去十年的技术进步增加了我们对卵巢癌相关生物学活动的分子机制的认识。了解这些机制在癌症发生和发展中的作用将有助于开发可针对每位患者个性化的预防和治疗方式，从而帮助克服这种高度致命的恶性肿瘤。
To review the current understanding of the underlying molecular, biologic and genetic mechanisms involved in ovarian cancer development and how these mechanisms can be targets for prevention, detection and treatment of the disease and its recurrence. In May 2012, we convened a meeting of researchers, clinicians and consumer advocates to review the state of current knowledge on molecular mechanisms and identify fruitful areas for further investigations. The meeting consisted of seven scientific sessions, ranging from Epidemiology, Early Detection, and Biology to Therapeutics and Quality of Life. Sessions consisted of talks and panel discussions by international leaders in ovarian cancer research. A special career-development session by the CDMRP Department of Defense Ovarian Cancer Academy as well as an oral abstract and poster session showcased promising new research by junior scientists. Technological advances in the last decade have increased our knowledge of the molecular mechanisms involved in a host of biological activities related to ovarian cancer. Understanding the role these mechanisms play in cancer initiation and progression will help lead to the development of prevention and treatment modalities that can be personalized to each patient, thereby helping to overcome this highly-fatal malignancy.