Implications of the Functional Integration of Adult-Born Hippocampal Neurons in Anxiety-Depression Disorders
Implications of the Functional Integration of Adult-Born Hippocampal Neurons in Anxiety-Depression Disorders
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DOI：
10.1177/1073858409360281
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发表时间：
2010-10-01
期刊：
影响因子：
5.6
通讯作者：
Hen, Rene
中科院分区：
文献类型：
--
作者：
David, Denis J.;Wang, Jingwen;Hen, Rene
成年人海马齿状回的神经发生作为抑郁症的病理生理学和治疗的细胞基质已经得到了相当大的关注。总体而言，成人海马神经发生的研究仍处于起步阶段，因为大多数人只探讨了这一过程的一个阶段。重要的是，考虑到在从干细胞到成熟神经元的进展过程中的每个阶段（增殖、分化、成熟、存活）起作用的内置稳态机制，很难从单独的一个阶段的分析来推断药物对成人神经发生的效率。在这里，我们回顾了海马神经发生的最重要的数据，重点研究成人海马神经发生的每个阶段的重要性，也选择适当的小鼠品系进行实验的重要性。具体而言，海马齿状回中具有大量基底增殖细胞的菌株应仅在应激条件下使用，以检测抗抑郁药对成人神经发生的影响。我们还讨论了成年海马神经发生如何参与情感状态障碍，如抑郁和焦虑。最后，我们揭示了氟西汀的行为效应是通过神经发生依赖性和非依赖性行为介导的。
Adult neurogenesis in the dentate gyrus of the hippocampus has gained considerable attention as a cellular substrate for both the pathophysiology and treatment of depression. Overall, the studies of adult hippocampal neurogenesis are still in their infancy because most of them explore only one stage of this process. Importantly, given the built-in homeostatic mechanisms that act at each stage during the progression from stem cells to mature neurons (proliferation, differentiation, maturation, survival), it is very difficult to extrapolate the efficiency of a drug on adult neurogenesis from analysis of one stage alone. Here, we review the most significant data on hippocampal neurogenesis, focusing on the importance of studying each stage of adult hippocampal neurogenesis and also on the importance of choosing the appropriate mouse strain to perform the experiment. Specifically, strains with a high number of basal proliferating cells in the dentate gyrus of the hippocampus should be used only under stressed conditions to detect the effects of antidepressants on adult neurogenesis. We also discuss how adult hippocampal neurogenesis could be involved in affective state disorders such as depression and anxiety. Finally, we reveal that the behavioral effects of fluoxetine are mediated through both neurogenesis-dependent and -independent actions.