Interactions of 5HT reuptake inhibitors and ethanol in tests of exploration and anxiety.
Interactions of 5HT reuptake inhibitors and ethanol in tests of exploration and anxiety.
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5HT 再摄取抑制剂和乙醇在探索和焦虑测试中的相互作用。
DOI：
10.1300/j251v07n03_18
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
M. Linnoila
中科院分区：
文献类型：
--
作者：
M. Durcan;R. Lister;M. Eckardt;M. Linnoila
已经证明用5 HT再摄取抑制剂治疗可以减少动物和人类的乙醇消耗。这些实验在小鼠中研究了5 HT再摄取抑制剂氟西汀、西酞普兰和氟伏沙明以及NA摄取抑制剂地昔帕明与乙醇在洞板测试和高架十字迷宫焦虑测试中的相互作用。乙醇（2.4 g/kg）增加了洞板和plusmaze中的活动，减少了洞板中头部下沉的次数和持续时间，并增加了进入plusmaze开放臂的百分比时间和百分比（反映了其抗焦虑特性）。选择性5-HT摄取抑制剂氟西汀、氟伏沙明和西酞普兰以及NA摄取抑制剂地昔帕明（10-20 mg/kg）本身并没有显著改变任何行为测量。唯一一致的相互作用是氟西汀，其在20 mg/kg剂量下降低乙醇的抗焦虑作用，而不改变乙醇对探索或运动的作用。结果表明，氟西汀对乙醇抗焦虑特性的衰减可能与5-羟色胺无关，因为其他5-HT再摄取抑制剂在所用剂量下未显示出这种效应。
Treatment with 5HT reuptake inhibitors has been shown to attenuate ethanol consumption in both animals and humans. These experiments investigate in mice the interactions of the 5HT reuptake inhibitors fluoxetine, citalopram and fluvoxamine and the NA uptake inhibitor desipramine with ethanol in the holeboard test and the elevated plusmaze test of anxiety. Ethanol (2.4 g/kg) increased activity both in the holeboard and on the plusmaze, decreased both the number and duration of head-dips in the holeboard, and increased both the percentage time and percentage entries on to the open-arm of the plusmaze (reflecting its anxiolytic properties). On their own, the selective 5HT uptake inhibitors fluoxetine, fluvoxamine, and citalopram and the NA uptake inhibitor desipramine (10-20 mg/kg) did not significantly alter any of the behavioral measures. The only consistent interaction was seen with fluoxetine which reduced ethanol's anxiolytic effects at the 20 mg/kg dose without altering ethanol's effects on exploration or locomotion. The results suggest that the attenuation of ethanol's anxiolytic properties by fluoxetine may not be serotonin related since other 5HT reuptake inhibitors did not show this effect at the doses used.