Diuretics in acute renal failure: Protective or deleterious
Diuretics in acute renal failure: Protective or deleterious
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DOI：
10.1159/000170350
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发表时间：
1997-07-01
影响因子：
3
通讯作者：
Kellum, JA
中科院分区：
文献类型：
--
作者：
Kellum, JA
急性肾功能衰竭（ARF）一词已被用于涵盖各种临床疾病，从肾小球肾炎到肾前氮血症。每一种潜在的疾病都有其独特的病理生理学，每一种疾病都有其独特的病因。此外，许多这些临床综合征都有特定的治疗方法。因此，如果不考虑我们所说的疾病的差异，就不可能考虑利尿剂是否对ARF有用的问题。此外，从诱导ARF的动物实验中获得的数据（如硝酸铀酰或甘油）必须谨慎解释，尽管如此，我们对这些疾病的大部分理解以及各种治疗的影响都来自这些模型。一般来说，利尿剂通常用于两大领域：预防和治疗急性肾小管坏死（ATN）。
The term acute renal failure (ARF) has been used to encompass a wide variety of clinical disor ders ranging from glomerulonephritis to prerenal azotemia. Each underlying disoder has its own unique pathophysiology and each has its own sep arate set of etiologies. Furthermore, many of these clinical syndromes have specific treatments. Ac cordingly, it is not possible to consider the issue of whether diuretics are useful in ARF without con sidering the differences in the disorders we are speaking of. Moreover, data drawn from animal experiments in which ARF was induced (such as uranyl nitrate or glycerol) must be interpreted with caution [1], Still, much of our understanding of these disorders, and the effects of various treat ments, comes from these models. In general, di uretics are usually considered in two broad areas: prevention and treatment of acute tubular necro sis (ATN).