Detection and Characterization of Metastatic Cancer Cells in the Mesogastrium of Gastric Cancer Patients.
Detection and Characterization of Metastatic Cancer Cells in the Mesogastrium of Gastric Cancer Patients.
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DOI：
10.1371/journal.pone.0142970
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gong J
中科院分区：
文献类型：
--
作者：
Xie D;Liu L;Osaiweran H;Yu C;Sheng F;Gao C;Hu J;Gong J
胃癌是全球第二大癌症死亡原因。在这里，我们提出了一种新型肿瘤转移，称为胃癌转移 V。转移V被定义为胃系膜中出现癌细胞并伴有胃周脂肪组织。为了检测其发病率并表征其临床病理特征，对 74 名患者的胃系膜进行大横截面组织分析。 40 名早期胃癌患者中有 1 名（2.5%）检测到转移 V，34 名晚期胃癌患者中有 8 名（24%）检测到转移 V。转移瘤 V 距胃壁的平均距离约为 2.6 厘米。转移V与肿瘤浸润深度密切相关，同时伴有阳性淋巴结转移的数量。转移V患者的预后明显差于胃系膜无肿瘤细胞患者（P<0.05）。这些结果表明，通过全断面分析，可以在胃癌患者的胃系膜中检测到转移V，也表明它可能是根治性手术后患者生存的危险因素。
Gastric cancer is the second leading cause of cancer death worldwide. Here, we propose a novel type of tumor metastasis designated as Metastasis V in gastric cancer. Metastasis V is defined as the appearance of cancer cells in the mesogastrium with perigastric adipose tissue. To detect its incidence and characterize its clinic pathological features, large cross sectional tissue analysis of mesogastrium from 74 patients were used. Metastasis V was detected in 1 of 40 (2.5%) patients with early gastric cancer, 8 of 34 (24%) patients with advanced gastric cancer. The mean distance of Metastasis V from gastric wall was approximately 2.6 cm. Metastasis V was closely associated with tumor invasion depth, along with a number of positive lymph node metastasis. The prognosis of patients with Metastasis V was significantly (P<0.05) worse than those with tumor cell-free mesogastrium. These findings indicate that by using whole-sectional analysis, Metastasis V can be detected in the mesogastrium of gastric cancer patients, and also suggests that it may be a risk factor for patient survival after radical surgery.