Practical preparation of N-(1-alkynyl)sulfonamides and their remote diastereoselective addition to aldehydes via titanation
Practical preparation of N-(1-alkynyl)sulfonamides and their remote diastereoselective addition to aldehydes via titanation
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DOI：
10.1021/ol036396b
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发表时间：
2004-03-04
期刊：
影响因子：
5.2
通讯作者：
Sato, F
中科院分区：
文献类型：
--
作者：
Hirano, S;Tanaka, R;Sato, F
在 CuI 催化存在下，用 1-溴-1-炔烃将脂肪族和芳香族磺酰胺进行炔基化，以良好至优异的收率得到 N-(1-炔基)磺酰胺。由 N-(1-炔基)苯磺内酰胺生成的乙炔-钛络合物经历非对映选择性加成到醛上。
Aliphatic and aromatic suffonamides were alkynylated with 1-bromo-1-alkynes in the catalytic presence of Cul to give N-(1-alkynyl)sulfonamides in good to excellent yields. The acetylene-titanium complexes generated from N-(1-alkynyl)benzosultams underwent diastereoselective addition to aldehydes.