Advances in D-Amino Acids in Neurological Research.

Advances in D-Amino Acids in Neurological Research.
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DOI:
10.3390/ijms21197325
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发表时间:
2020-10-03
影响因子:
5.6
通讯作者:
Lewis SJ
Lewis SJ
中科院分区:
生物学2区
文献类型:
--
作者:
Seckler JM;Lewis SJ

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d -氨基酸在人类大脑中已经存在了近40年,直到今天,它们仍然是一个活跃的研究领域。本文综述了d -氨基酸与大脑和神经系统疾病相关的最新研究进展。这项工作主要集中在n -甲基- d -天冬氨酸(NMDA)受体的调节及其与阿尔茨海默病和精神分裂症的关系上,但已经有大量的新研究阐明了几种d -氨基酸在以神经保护方式改变脑化学中的新作用。d -氨基酸目前在大脑中没有已知的活性,但有活性衍生物,也将被审查。
D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to the brain and neurological disorders. This work has largely been focused on modulation of the N-methyl-D-aspartate (NMDA) receptor and its relationship to Alzheimer’s disease and Schizophrenia, but there has been a wealth of novel research which has elucidated a novel role for several D-amino acids in altering brain chemistry in a neuroprotective manner. D-amino acids which have no currently known activity in the brain but which have active derivatives will also be reviewed.
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