Virological, pathological, and glycovirological investigations of an Ezo red fox and a tanuki naturally infected with H5N1 high pathogenicity avian influenza viruses in Hokkaido, Japan
Virological, pathological, and glycovirological investigations of an Ezo red fox and a tanuki naturally infected with H5N1 high pathogenicity avian influenza viruses in Hokkaido, Japan
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DOI：
10.1016/j.virol.2022.11.008
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发表时间：
2022-12-01
期刊：
影响因子：
3.7
通讯作者：
Sakoda, Yoshihiro
中科院分区：
文献类型：
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作者：
Hiono, Takahiro;Kobayashi, Daiki;Sakoda, Yoshihiro
2021-2022年冬春季，在世界范围内发现了基因上密切相关的高致病性禽流感病毒(HPAIV)。2022年3月29日至5月18日，在日本北海道札幌市的一个公园里，发生了一只因感染HPAIV而死亡的乌鸦。在活动期间，从在同一花园中发现的一只Ezo红狐(Vulpe Wwpe Schrencki)和一只Tanuki(Nycteretus Proyonodes Albus)分离到H5N1 HPAIV。狐狸表现为病毒性脑膜脑炎和病毒在上呼吸道的中度复制，而斑羚则表现为病毒性结膜炎和继发性细菌感染，并伴有内脏幼虫迁徙。从狐狸和Tanuki身上分离出的病毒在基因上与从同一花园的乌鸦中分离到的病毒密切相关。在这些犬科哺乳动物的呼吸道中发现了各种a2-3唾液酸苷，这与这些动物感染HPAIV的情况一致。这项研究强调了监测野生食肉哺乳动物中HPAIV感染的重要性，以检测潜在的病毒在自然界中的传播。
In winter/spring 2021-2022, high pathogenicity avian influenza viruses (HPAIVs) that are genetically closely related to each other were detected worldwide. In a public garden in Sapporo, Hokkaido, Japan, a crow die-off by HPAIV infection occurred from March 29 to May 18, 2022. During the event, H5N1 HPAIVs were isolated from an Ezo red fox (Vulpes vulpes schrencki) and a tanuki (Nyctereutes procyonoides albus) found in the same garden. The fox showed viral meningoencephalitis and moderate virus replication in the upper respiratory tract, whereas the tanuki showed viral conjunctivitis and secondary bacterial infection in the eyes accompanied with visceral larva migrans. Viruses isolated from the fox and the tanuki were genetically closely related to those isolated from crows in the same garden. Various a2-3 sialosides were found in the respiratory tracts of these canid mammals, consistent with HPAIV infections in these animals. This study highlighted the importance of monitoring HPAIV infections in wild carnivore mammals to detect the potential virus spreading in nature.