Speech Perception Ability in Noise is Correlated with Auditory Brainstem Response Wave I Amplitude
Speech Perception Ability in Noise is Correlated with Auditory Brainstem Response Wave I Amplitude
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DOI：
10.3766/jaaa.14100
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发表时间：
2015-05-01
影响因子：
1.2
通讯作者：
Parker, Mark
中科院分区：
文献类型：
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作者：
Bramhall, Naomi;Ong, Bonnie;Parker, Mark
背景：在背景噪音中理解语音困难是感音神经性听力损失患者的常见症状。最近的动物研究表明，这种困难可能部分归因于与衰老或噪音暴露相关的螺旋神经节细胞退化。尽管听觉脑干反应 (ABR) 阈值和标准临床听力测试受神经元变性的影响很小，但 ABR 的波 I 的幅度与螺旋神经节细胞密度相关。 目的：本研究假设波 I 的幅度与噪声中的语音表现相关。为了测试这一点，我们对人类参与者的 I 波振幅、年龄和言语感知能力之间的关系进行了分析。研究设计：这是一项相关研究。研究样本：本研究共检查了 57 名成年人的 101 只耳朵，年龄从 19 岁到 90 岁，纯音平均值为 45 dB HL 或更好。仅包括没有神经系统疾病史和没有任何传导参与证据的耳朵的个体。 数据收集和分析：使用 NU-6 单词列表在安静条件下测量言语感知，并使用 QuickSIN 在背景噪声下测量言语感知。使用耳道电极从每只耳朵获取 ABR 波形，并测量波 I 的振幅，即波峰与随后的波谷之间的电压绝对差。安静和背景噪声下的语音感知性能均使用线性混合模型进行建模，其中包含协变量年龄、四频纯音平均值 ((4f)PTA)、波 I 幅度以及 (4f)PTA 和波 I 幅度之间的相互作用。使用以年龄和 (4f)PTA 作为协变量的线性混合模型对 ABR 波 I 振幅进行建模。使用随机效应对同一参与者的右耳和左耳之间的相关性进行建模。结果：结果表明，ABR 波 I 波幅减小与 (1) 年龄增加有关，(2) 与噪声中言语表现下降相关，对纯音阈值较差的个体影响最大，(3) 与安静时的言语感知无关。结论：ABR 波 I 波幅减小是耳蜗神经元退化的指标，与噪声中言语感知能力下降相关，对于纯音阈值较差的耳朵，效果更明显，但似乎不会导致安静时言语感知的下降。
Background: Difficulty understanding speech in background noise is a common complaint of individuals with sensorineural hearing loss. Recent animal studies suggest this difficulty may be due, in part, to spiral ganglion cell degeneration related to aging or noise exposure. Although auditory brainstem response (ABR) thresholds and standard clinical audiometric tests are minimally affected by neuronal degeneration, the amplitude of wave I of the ABR is correlated to spiral ganglion cell density.Purpose: This study hypothesized that wave I amplitude was correlated to speech-in-noise performance. To test this, the relationships between wave I amplitude, age, and speech perception ability were analyzed in human participants.Research Design: This is a correlational study. Study Sample: A total of 101 ears from 57 adults ranging in age from 19 to 90 yr with a pure-tone average of 45 dB HL or better were examined in this study. Only individuals with no history of neurological disease and ears without any evidence of conductive involvement were included.Data Collection and Analysis: Speech perception was measured in quiet using NU-6 word lists and in background noise using the QuickSIN. Ear canal electrodes were used to obtain ABR waveforms from each ear and the amplitude of wave I was measured as the absolute difference in voltage between the peak of the wave and the following trough. Speech perception performance in quiet and in background noise were both modeled using a linear mixed model with the covariates age, four-frequency pure-tone average ((4f)PTA), wave I amplitude, and the interaction between (4f)PTA and wave I amplitude. ABR wave I amplitudes were modeled using a linear mixed model with age and (4f)PTA as the covariates. The correlation between the right and left ears of the same participant were modeled using random effects.Results: The results indicate that reduced ABR wave I amplitudes are (1) related to increased age, (2) associated with decreased speech-in-noise performance, with the greatest effects in individuals with poorer pure-tone thresholds, and (3) not correlated to speech perception in quiet.Conclusions: Reduced ABR wave I amplitude, an indicator of cochlear neuronal degeneration, is associated with decreased speech perception ability in noise, with a more pronounced effect in ears with poorer pure-tone thresholds, but does not appear to contribute to decreased speech perception in quiet.