In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome
In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome
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DOI：
10.1016/s0015-0282(98)00146-0
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发表时间：
1998-08-01
影响因子：
6.7
通讯作者：
Thompson, W
中科院分区：
文献类型：
--
作者：
Donnelly, ET;Lewis, SEM;Thompson, W
目的：探讨精子活动率和精子形态参数与体外受精和妊娠率的关系。设计：不育夫妇体外受精前后精液标本分析。单位：贝尔法斯特皇家妇产医院男科实验室，患者(S)：150对夫妇在区域生育中心接受体外受精-胚胎移植治疗。干预(S)：无。主要观察指标(S)：研究人类精子实现体外受精和妊娠的能力与精子运动参数(用计算机辅助精子分析[集成视觉光学系统]评估)和正常形态百分比(按严格标准确定)的关系。结果(S)：受精率大于或等于50%的受精者与受精率小于或等于50%的受精者之间以及受孕者与未受精者之间的运动参数和正常形态百分比均有显著差异。精子前向运动百分率、精子运动速度和形态参数与体外受精和妊娠均呈显著正相关。结论：精子运动参数和形态正常率均是预测体外受精和妊娠率的重要因素。(Fertil Steril(R)1998；70：305-14.(C)1998年美国生殖医学学会。)。
Objective: To determine the relationship between sperm motility and sperm morphology parameters and IVF and pregnancy rates.Design: Pre- and postpreparation analysis of semen samples from infertile couples undergoing IVF-ET.Setting: Andrology Laboratory, Royal Maternity Hospital, Belfast, Northern Ireland.Patient(s): One hundred fifty couples undergoing IVF-ET treatment at the Regional Fertility Centre.Intervention(s): None.Main Outcome Measure(s): The ability of human sperm to achieve IVF and pregnancy was investigated in relation to motility parameters (assessed with computer-aided sperm analysis [Integrated Visual Optical System] and percent normal morphology (determined with the strict criteria).Result(s): Significant differences were observed in motility parameters and percent normal morphology in samples that achieved greater than or equal to 50% fertilization compared with less than or equal to 50% fertilization and between samples that achieved a pregnancy compared with those that did not. Significant positive correlations were observed between percent progressive motility, the velocity of sperm movement, and morphology parameters and both IVF and pregnancy.Conclusion(s): Both sperm motility parameters and percent normal morphology are significant factors in predicting fertilization and pregnancy rates in IVF. (Fertil Steril(R) 1998;70:305-14. (C)1998 by American Society for Reproductive Medicine.).